The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is encoded by the BCR gene. BCR is one of the two genes in the BCR-ABL fusion protein, which is associated with the Philadelphia chromosome.

Mar 30, 2025 · Complete information for BCR gene (Protein Coding), BCR Activator Of RhoGEF And GTPase, including: function, proteins, disorders, pathways, orthologs, and expression.

The BCR gene provides instructions for making a protein whose function is not completely understood. Studies show that the BCR protein may act as a GTPase activating protein (GAP). GAPs turn off (inactivate) proteins called GTPases, which play an important role in chemical signaling within cells.

This review explores the mechanisms behind cancer progression of these BCR oncogenic fusion proteins, comparing their similarities and differences, examining the significance of BCR as a partner gene, and discussing current treatment options for these translocation-induced hematopoietic malignancies.

Dec 20, 2023 · Bcr gene is a gene that plays a crucial role in the development of chronic myelogenous leukemia and is the target of a revolutionary drug called imatinib, which has significantly improved the prognosis for patients with this type of cancer.

Bcr-abl regulates number of biological processes such as cell propagation, cell survival and cell trafficking. Importantly, overexpression of Bcr-abl induces chemo-resistance in CML [174]. Thus BCR-abl could be an essential therapeutic target in AML, ALL, and CML treatment [174].

Breakpoint cluster region (BCR) is a gene that functions as a fusion partner with ABL1 to encode a fusion protein that is a result of the reciprocal translocation between chromosomes 22 and 9. The translocation produces the Philadelphia chromosome - a hallmark feature of chronic myelogenous leukemia (CML).

Apr 7, 2025 · Chronic myeloid leukemia (CML) is a kind of leukemia that arises due to the translocation betwixt chromosomes 9 and 22. Philadelphia chromosome is characterized by the BCR::ABL fusion gene, which results from this recombination. It transcribes into active tyrosine kinase variants such as P185, P190, …

The occurrence of different BCR‐ABL1 mRNA fusion variants (most commonly e13‐a2, e14‐a2, and e1‐a2) results in the expression of an abnormal BCR‐ABL1 fusion tyrosine kinase in the majority of the patients. In most cases, the breakpoints occur within the major breakpoint cluster region (M‐bcr) within the BCR gene.

Apr 14, 2025 · Oncogenic gene fusions occur frequently (or are a defining feature) in certain types of cancer. 6, 7, 8 For example, the BCR-ABL fusion – which gives rise to an aberrant, constitutively active ...