The B-cell receptor (BCR) is a transmembrane protein on the surface of a B cell. A B-cell receptor is composed of a membrane-bound immunoglobulin molecule and a signal transduction moiety.

Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells.

The B cell receptor (BCR) covers the surface of mature B cells, and initiates cellular responses that lead to B cell activation and antibody production. Each B cell expresses a unique B cell receptor with specificity for a unique antigen.

Jul 8, 2019 · BCR signaling has been shown to govern the initiation of transcriptional programs associated with B cell activation and fate decisions, as well as the BCR-dependent processing of antigen and...

Jan 12, 2025 · The B cell receptor complex is a sophisticated molecular assembly integral to the immune system’s ability to recognize and respond to antigens. At its core, the BCR is composed of membrane-bound immunoglobulin molecules that serve as the antigen-binding component.

Constitutive active BCR signaling is essential for the generation and maintenance of age-associated B cells from anergic B cells. INTRODUCTION Autoreactive B cells play a crucial role in autoimmunity. B cell depletion therapies broadly targeting B cells are currently in clinical use for treating autoimmune diseases.

1 day ago · What is a B cell receptor? A B cell receptor (BCR) is a molecule found on the surface of B cells, a type of white blood cell. BCRs play a crucial role in the immune system by recognizing and binding to specific antigens, which are substances that can trigger an immune response. When a BCR binds to an antigen, it activates the B cell, leading to the production of antibodies that help neutralize ...

These BCR microclusters are the sites for the coordinated recruitment of the signalosome and are propagated during B cell spreading. We discuss the recent identification of a critical role for CD19 in the B cell response to membrane-bound antigen and suggest a mechanism involving BCR microclusters by which it mediates its stimulatory function.

Mar 14, 2025 · B cell receptor (BCR) signaling is essential for the adaptive immune response, guiding B cells in recognizing antigens and initiating immune defense. This process ensures effective pathogen neutralization while maintaining tolerance to self-antigens, preventing autoimmune reactions.

Mar 11, 2025 · B cell receptors (BCRs) are crucial for the immune system’s recognition and response to pathogens. Their structure enables B cells to detect specific antigens, triggering an immune response vital for pathogen elimination.