Several genomic studies have revealed that ∼20% of malignancies have alterations of the subunits of polymorphic BRG-/BRM-associated factor (BAF) and Polybromo-associated BAF (PBAF) complexes, making them among the most frequently mutated complexes in cancer.

Aug 1, 2016 · We review several roles of BAF and PBAF complexes in cancer, including transcriptional regulation, DNA repair, and regulation of chromatin architecture and topology. More recent results highlight the need for new techniques to study these complexes.

Dec 10, 2022 · BAF and PBAF are mammalian SWI/SNF family chromatin remodeling complexes that possess multiple histone/DNA-binding subunits and create nucleosome-depleted/free regions for...

Jun 13, 2023 · Depletion of the canonical SWI/SNF form, BAF, impaired initial CD8 + T cell responses in acute and chronic infection. In contrast, disruption of PBAF enhanced Tex-cell proliferation and survival.

3 days ago · Further complicating the functional dissection of individual SWI/SNF complexes is the modular nature of these macromolecular assemblies that generally exist in three distinct conformations, known as canonical BAF (cBAF), non-canonical BAF (ncBAF), and polybromo-associated BAF (PBAF). 6 These subfamilies are characterized by unique components, as well as several common core subunits including ...

Jun 13, 2023 · Together, BAF and PBAF cooperated to epigenetically regulate Tex subset differentiation. Depleting PBAF improved antitumor immunity, an effect further enhanced by PD-1 pathway blockade, suggesting that rewiring Tex cells by manipulating SWI/SNF complexes could enhance immunotherapy.

Feb 21, 2020 · Mammalian SWI/SNF family chromatin remodelers, BRG1/BRM-associated factor (BAF) and polybromo-associated BAF (PBAF), regulate chromatin structure and transcription, and their mutations are linked to cancers. The 3.7-angstrom-resolution cryo-electron microscopy structure of human BAF bound to the nuc …

Two of the main human SWI/SNF complexes are BRG1 associated factors, BAF and Polybromo-associated BAF, PBAF. They share a conserved set of nine proteins, including the catalytic ATPase, Brahma-related gene 1 (BRG1) or Brahma (BRM) and are distinguished by unique AT-rich interactive domain-containing (ARID) proteins: ARID1A or ARID1B (BAF250A/B ...

Several genomic studies have revealed that 20% of malignan-cies have alterations of the subunits of polymorphic BRG-/BRM-associated factor (BAF) and Polybromo-associated BAF (PBAF) complexes, making them among the most frequently mutated complexes in cancer.

BAF and PBAF are mammalian SWI/SNF family chromatin remodeling complexes that possess multiple histone/DNA-binding subunits and create nucleosome-depleted/free regions for transcription activation.