Autophagy was activated significantly after I/R injury, which was partially inhibited by 3-MA and BAF. Pretreatment with both 3-MA and BAF almost completely inhibited nuclear translocation, spatial overlap, and combination of RIP3, AIF, and CypA proteins.

The BA/F3 cell line, originating from murine pro-B cells of the BALB/c mouse strain, is a cornerstone in drug discovery and development, where BaF3 cells are commonly used to test the efficacy of small molecule inhibitors targeting oncogenic kinases.

Oct 13, 2020 · Here, we present a three-dimensional (3D) structural model of the endogenously purified human canonical BAF complex bound to the nucleosome using a combination of single-particle cryo-EM, cross-linking mass-spectrometry (CX-MS), and homology modeling.

Ba/F3 is a murine, IL‐3‐dependent, pro‐B cell line, which is a popular system that can resolve the limited availability of lung cancer patient‐derived cells with rare driver mutations.

Oct 29, 2020 · Here, we present a structural model of the endogenously purified human canonical BAF complex bound to the nucleosome, generated using cryoelectron microscopy (cryo-EM), cross-linking mass spectrometry, and homology modeling.

Recent findings: Ba/F3, a murine interleukin-3 dependent pro-B cell line is increasingly popular as a model system for assessing both the potency and downstream signaling of kinase oncogenes, and the ability of small-molecule kinase inhibitors to block kinase activity.

In this review, we focus on the family of BRG-/BRM-associated factor ( [BAF] or mSWI/SNF) and Polybromo-associated BAF (PBAF) complexes, whose subunits have been identified as major tumor suppressors in several malignancies (Davoli et …

Sep 5, 2014 · In particular, the neural progenitor-specific BAF complexes are essential for controlling the kinetics and mode of neural progenitor cell division, while neuronal BAF function is necessary for the maturation of postmitotic neuronal phenotypes as …

Our findings suggest a novel SMARCC2-related syndrome that overlaps with neurodevelopmental disorders associated with variants in BAF-complex subunits. Keywords: developmental delay, intellectual disability, neurodevelopmental disorder, Bafopathy, transcriptome, genotype-phenotype correlation, speech delay, dysmorphisms.

BAF in Medical commonly refers to B-cell Activating Factor, a cytokine involved in the regulation of B-cell development and function within the immune system. This factor plays a crucial role in the survival and proliferation of B-cells, which are essential for antibody production.