Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 is an enzyme that in humans is encoded by the ATP2A3 gene. [5] [6] This gene encodes one of the SERCA Ca 2+-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of cells.

Mar 30, 2025 · ATP2A3 (ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 3) is a Protein Coding gene. Diseases associated with ATP2A3 include Darier-White Disease and Acrokeratosis Verruciformis. Among its related pathways are Cardiac conduction and Pre-NOTCH Expression and Processing.

Feb 8, 2025 · This study demonstrates that ATP2A3 might be one of the potential targets for salinomycin, which can inhibit Ca(2+) release and trigger ER stress to exert anti-cancer effects. Sp1, Sp3, and Klf-4 transcription factors bind to ATP2A3 proximal promoter elements and regulate basal gene expression.

ATP2A3 is a prognostic marker in Cervical squamous cell carcinoma and endocervical adenocarcinoma, Head and neck squamous cell carcinoma, Kidney renal clear cell carcinoma

Our results demonstrate that RSV treatment induced the expression of ATP2A3 gene in both cell lines in a time and concentration-dependent manner, while the expression of ATP2A2 gene remained unaffected.

Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. This reaction proceeds in the forward direction. Inhibited by sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity).

The SERCA (sarcoplasmic/endoplasmic reticulum Ca 2+ -ATPase) is encoded by three different genes ATP2a1, ATP2a2 and ATP2a3, each of which gives rise to multiple isoforms by alternative splicing of their 3′ end. ATP2a3 generates at least seven alternatively spliced SERCA 3 …

Feb 8, 2025 · Induction of cell differentiation activates transcription of the Sarco/Endoplasmic Reticulum calcium-ATPase 3 gene (ATP2A3) in gastric and colon cancer cells. Loss of endoplasmic reticulum calcium pump expression in choroid plexus tumours. Aberrant SERCA3 expression during the colorectal adenoma-adenocarcinoma sequence.

ATPase, Ca++ transporting, ubiquitous [Source:HGNC Symbol;Acc: 813] SERCA3. Chromosome 17: 3,827,169-3,867,736 reverse strand. GRCh37:CM000679.1. This gene has 16 transcripts (splice variants) and 4 paralogues. Show transcript table.

A gene on chromosome 17p13.3 that encodes a SERCA Ca2+-ATPase, an intracellular pump located in the sarcoplasmic or endoplasmic reticula of muscle cells, which catalyses the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscle contraction and relaxation.