Astrocyte transcriptomic changes along the spatiotemporal …
Dec 6, 2024 · This was an ambitious study using single-nucleus RNA-Seq to characterize astrocyte heterogeneity across five brain regions in 32 donors who spanned the spectrum of …
Astrocyte Reactivity: Opposing States Emerge | ALZFORUM
Jun 30, 2022 · A cocktail of cytokines triggers at least two opposing astrocyte reactions that balance each other. Controlled by STAT3, one churns out IL-6; the other unleashes …
Aβ Clearance—The Untapped Potential of Astrocytes? - ALZFORUM
Nov 9, 2021 · Astrocyte With Appetite. Cultured mouse astrocytes treated with gemfibrozil and retinoic acid (right) ingurgitated more Aβ (white) than did untreated cells (left), and …
Astrocytes Mount Complex Responses to AD. They Change Over …
Dec 5, 2024 · “The coexistence of multiple astrocyte phenotypes suggests that we should address astrocyte heterogeneity, stratify astrocyte subtypes, and consider multiple astrocyte targets for …
Border Surprise: Glia Limitans Astrocytes Sit on Brain Surface
Nov 4, 2023 · Some previous studies have also found astrocyte cell bodies on the brain’s surface (Feig and Haberly, 2011; Falcone et al., 2021), and one reported these cells were myocilin+ …
APOE from astrocytes restores Alzheimer's Aβ-pathology and …
Dec 4, 2024 · Astrocyte-microglia interactions are thought to be central factors driving early AD neuropathology, so the authors first explored the relationship between astrocyte …
In Amyloid Cascade, Do Reactive Astrocytes Bridge Plaques
Jun 2, 2023 · Reactive astrocyte nomenclature, definitions, and future directions. Nat Neurosci. 2021 Mar;24(3):312-325. Epub 2021 Feb 15 PubMed. Bellaver B, Ferrari-Souza JP, Uglione …
Over the Span of AD, Roles of Astrocytes and Microglia Change
First, Bellaver investigated how astrocyte reactivity influenced the relationship between amyloid status, as gauged by PET or plasma Aβ42/40 levels, and plasma p-tau217. She found that …
New Astrocyte Marker Allows Purification from Mixed Cultures
Jun 5, 2020 · Importantly, 97 percent of the cells expressed aquaporin 4, a key astrocyte marker, suggesting this was a fairly pure astrocyte population (see image above). Most of the cells …
Old Cytokine, New Tricks? Astrocyte IL-3 Pokes Microglia in AD
Jul 16, 2021 · More broadly, astrocyte-derived IL3 has been found to be: implicated as a microglial growth factor (Frei et al., 1986); important for neural development (Luo et al., 2012); …