Jun 24, 2023 · In patients with asthma, the physiologic mechanism changes due to inflammation, decreasing the radius of the airway. All of these mechanisms together change the compliance of the lungs slightly to increase the work of breathing.

Asthma endotypes describe these distinct pathophysiologic mechanisms at a cellular and molecular level. Despite similar clinical symptoms, patients may respond very differently to the same therapeutic interventions.

Dissecting out the individual asthmas is increasingly important as novel biologicals with different modes of action are increasingly being deployed. The ultimate aim is to discover endotypes of asthma, but currently we have not yet got to this point.

May 3, 2024 · Asthma is a syndrome characterized by diverse underlying mechanisms and involves intricate interactions among inflammatory and resident airway cells. These mechanisms lead to airway inflammation, intermittent airflow obstruction, and …

During an asthma episode, inflamed airways react to environmental triggers such as smoke, dust, or pollen. The airways narrow and produce excess mucus, making it difficult to breathe. In essence, asthma is the result of an immune response in the bronchial airways. [3]

Asthma is a chronic inflammatory disorder of the airways. This feature of asthma has implications for the diagnosis, management, and potential prevention of the disease. Airway inflammation contributes to airway hyperresponsiveness, airflow limitation, respiratory symptoms, and …

Asthma is associated with immune system activation, airway hyperresponsiveness (AHR), epithelial cell activation, mucus overproduction and airway remodeling. Both innate and adaptive immunity play roles in immunologic mechanisms of asthma. Type 2 asthma with eosinophilia is a common phenotype in asthma. It occurs with and without visible allergy.

Sep 5, 2022 · Asthma is a heterogeneous lung disease with variable phenotypes (clinical presentations) and distinctive endotypes (mechanisms). Over the last decade, considerable efforts have been made to dissect the cellular and molecular mechanisms of asthma.

Asthma is a heterogeneous disease process with varying phenotypes and presentations. In this chapter, we will briefly explore some major theories of asthma pathogenesis, both new and old.

May 1, 2016 · Asthma is associated with chronic inflammation of the lower airways mucosa and is usually controlled when the inflammation is effectively suppressed by corticosteroids. The pathology of asthma has been elucidated from bronchial biopsies and by studying the lungs of patients who have died of asthma.