Feb 19, 2020 · Wnt/β-catenin signaling is essential for intestinal homeostasis and is aberrantly activated in most colorectal cancers (CRC) through mutation of the tumor suppressor Adenomatous Polyposis...

APC, WNT signaling pathway regulator is a protein that in humans is encoded by the APC gene. [4] This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis.

Jan 3, 2022 · Recently, Ji et al. found that ICAT is a natural inhibitor of APC that plays a positive role in Wnt signal transduction by blocking APC-mediated degradation of β-catenin.

Jul 19, 2023 · Here, we demonstrate the role of oncogenic APC in increasing plasma membrane free cholesterol and rigidity, thereby modulating Wnt signaling hubs. This results in an overactivation of Wnt...

Apr 2, 2025 · Adenomatous polyposis coli (APC) APC is a tumor suppressor gene that regulates β-catenin degradation [65, 66].However, alterations in the APC gene impair Wnt signaling pathways, triggering the abnormal accumulation of β-catenin and facilitating the progression of tumors (Fig. 1).The identification of APC gene mutations serves as a fundamental biomarker, distinguishing cancer patients with ...

By negatively regulating canonical WNT signaling, APC counteracts proliferation, promotes differentiation, facilitates apoptosis and suppresses invasion and tumor progression. APC further antagonizes canonical WNT signaling by interacting with and counteracting β …

Wnt growth factors activate a cascade of intracellular events, which is known as the canonical Wnt pathway that ultimately leads to the expression of a genetic program controlling the co‐ordinated expansion, fate and sorting of the epithelial cell population.

Feb 19, 2020 · APC is an essential component of a cytoplasmic protein complex that targets β-catenin for destruction. Following Wnt ligand presentation, this complex is inhibited. However, a role for APC in this inhibition has not been shown. Here, we utilized Wnt3a-beads to locally activate Wnt co-receptors.

Oct 17, 2017 · The tumor suppressor gene adenomatous polyposis coli (APC) is mutated in most colorectal cancers (CRCs), resulting in constitutive Wnt activation. To understand the Wnt-activating mechanism of the APC mutation, we applied CRISPR/Cas9 technology to engineer various APC-truncated isogenic lines.

Nov 7, 2013 · APC normally down-regulates WNT signaling in human colon, and APC mutations cause proliferative abnormalities in premalignant crypts leading to colon cancer, but the mechanisms are unclear at the level of spatial and functional organization of the crypt.