Ankyrins are a family of proteins that mediate the attachment of integral membrane proteins to the spectrin - actin based membrane cytoskeleton. [2] . Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins.

Ankyrins are a family of adaptor proteins that link integral membrane proteins with the submembranous actin/β-spectrin cytoskeleton. The first ankyrin was characterized over 30 years ago as an adaptor protein that tethered the anion exchanger to β-spectrin in red blood cells [1].

Ankyrin repeats typically fold together to form a single, linear solenoid structure called ankyrin repeat domains. These domains are one of the most common protein–protein interaction platforms in nature. They occur in a large number of functionally diverse proteins, mainly from …

Ankyrins are broadly expressed adaptors that organize diverse membrane proteins into specialized domains and link them to the sub-membranous cytoskeleton. In neurons, ankyrins are known to have essential roles in organizing the axon initial segment and nodes of Ranvier.

The protein encoded by the ANK3 gene is a member of the ankyrin family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton. Ankyrins play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains.

Ankyrins are adaptor molecules that in eukaryotic cells form complexes with ion channel proteins, cell adhesion and signalling molecules and components of the cytoskeleton. They play a pivotal role as scaffolding proteins, in the structural anchoring to the muscle membrane, in muscle development, neurogenesis and synapse formation.

Nov 24, 2020 · Ankyrins (Ank) are ubiquitously expressed proteins that play a critical role in the integrity of cytoskeleton and cellular signalling. Their presence in metazoans and evolutionary conserved protein primary sequence indicates their functional significance.

Recent data on characteristics of the structure, functions, and main properties of ankyrins (proteins that are linkers between the spectrin-based cytoskeleton and integral membrane proteins) are summarized. The interactions of ankyrins with band-3 protein, P-type ATPases, ion channels, receptors, and protein kinase C are considered.

Ankyrin is a binding protein linking structural proteins of the cytoplasm to spectrin, a protein present in the membrane cytoskeleton in human erythrocytes [1] that functions as an anchoring system to provide resistance to shear stress.

Jul 6, 2022 · Ankyrin proteins act as molecular scaffolds and play an essential role in regulating cellular functions. Recent evidence has implicated the ANK3 gene, encoding ankyrin-G, in bipolar disorder...