In the fields of biochemistry and pharmacology an allosteric regulator (or allosteric modulator) is a substance that binds to a site on an enzyme or receptor distinct from the active site, resulting in a conformational change that alters the protein's activity, either enhancing or inhibiting its function.

The meaning of ALLOSTERIC is of, relating to, undergoing, or being a change in the shape and activity of a protein (such as an enzyme) that results from combination with another substance at a point other than the chemically active site.

Allosteric enzymes are enzymes that change their conformational ensemble upon binding of an effector (allosteric modulator) which results in an apparent change in binding affinity at a different ligand binding site.

The allosteric site is regulatory in function and it provides a binding site for the effectors that either activate or inhibit the enzyme’s catalytic efficiency. This post mainly describes the definition, features, examples, types and models of allosteric regulation.

Allosteric enzymes are enzymes that have an additional binding site for effector molecules other than the active site. The binding brings about conformational changes, thereby changing its catalytic properties.

Jan 23, 2024 · “Allosteric” was first introduced to mean the other site (i.e., a site distinct from the active or orthosteric site), an adjective for “regulation” to imply a regulatory outcome resulting from ligand binding at another site.

This Focus issue highlights allostery in key proteins, membrane-spanning receptors, and soluble hub proteins, as well as methods to predict allosteric residues, communication pathways, and allosteric sites.

Inhibitors and other molecules, called activators, that bind to enzymes at allosteric sites are considered an important part of enzyme regulation called allosteric control. In this section, we will take a look at allosteric control and feedback control, two ways in which enzyme activity is regulated differently.

Define allosterism and distinguish between allosteric binding at orthosteric versus allosteric sites. Explain how environmental factors (ligands, substrates, ions, and other effectors) influence protein conformation and cooperativity.

Mar 21, 2023 · Allosteric regulation is a critical mechanism for controlling enzyme activity and regulating cellular processes. It allows cells to respond to changes in their environment and adjust their metabolic processes accordingly.