Aldehydes to Amides via Oxidative Cleavage. If the conversion of the aldehyde to amide shortens the carbon chain, then the process may involve some oxidative cleavage of a π bond. For example, we can convert the aldehyde to an alkene, cleavage the double bond forming a carboxylic acid, and then covert the latter to an amide:

An amide formation using primary amines and potassium acyltrifluoroborates, that proceeds rapidly in water, is promoted by simple chlorinating agents. The reaction is fast at acidic pH and tolerates alcohols, carboxylic acids, and even secondary amines in the substrates.

Jul 31, 2021 · For the preparation of amides of the type \(\ce{R_3CNHCOR}\), which have a tertiary alkyl group bonded to nitrogen, the Ritter reaction of an alcohol or alkene with a nitrile or hydrogen cyanide is highly advantageous. This reaction involves formation of a carbocation by action of strong sulfuric acid on an alkene or an alcohol (Equation 24-2 ...

A one-pot synthesis of amides from aldheydes with N-chloroamines, prepared in situ from amines, has been developed. Both aliphatic and aromatic aldehydes and many types of mono- and disubstituted a...

A variety of aldehydes reacted with iodine in ammonia water at room temperature to give the nitrile intermediates, which were trapped by addition of hydrogen peroxide, sodium azide, or dicyandiamide to produce their corresponding amides, tetrazoles, and 1,3,5-triazines in modest to …

A photoorganocatalytic reaction of aldehydes with diisopropyl azodicarboxylate leads to an intermediate carbonyl imide, which can react with a variety of amines to afford amides. This method enables a mild, one-pot, and environmentally …

Sodium perborate in acetic acid is an effective reagent for the oxidation of aromatic aldehydes to carboxylic acids, iodoarenes to (diacetoxyiodo)arenes, azines to N-oxides, and various sulphur heterocycles to S,S-dioxides. Nitriles undergo smooth oxidative hydration to amides when aqueous methanol is employed as solvent.

Jul 1, 2017 · With the concept of ‘green chemistry’ and ‘sustainable development’, the synthesis of amides from the condensation of easy availability aldehyde or alcohols with amines is of great interest. Using CuI as catalyst, Huang and co-workers [10] realized the synthesis of N -pyridinamides in DMF at 80 °C.

A facile one-pot synthesis of amides from aldehydes has been developed. This tandem process involves the formation of a nitrile intermediate obtained from the reaction of an

Jun 8, 2010 · A facile one-pot synthesis of amides from aldehydes has been developed. This tandem process involves the formation of a nitrile intermediate obtained from the reaction of an aldehyde with hydroxylamine hydrochloride in dimethylsulfoxide at 100°C and the subsequent treatment of the nitrile with basic hydrogen peroxide.