Ankyrins are a family of proteins that mediate the attachment of integral membrane proteins to the spectrin - actin based membrane cytoskeleton. [2] . Ankyrins have binding sites for the beta subunit of spectrin and at least 12 families of integral membrane proteins.

The ankyrin repeat is a 33-residue motif in proteins consisting of two alpha helices separated by loops, first discovered in signaling proteins in yeast Cdc10 and Drosophila Notch. Domains consisting of ankyrin tandem repeats mediate protein–protein …

Ankyrins are a family of adaptor proteins that link integral membrane proteins with the submembranous actin/β-spectrin cytoskeleton. The first ankyrin was characterized over 30 years ago as an adaptor protein that tethered the anion exchanger to β-spectrin in red blood cells [1].

Ankyrins are adaptor molecules that in eukaryotic cells form complexes with ion channel proteins, cell adhesion and signalling molecules and components of the cytoskeleton. They play a pivotal role as scaffolding proteins, in the structural anchoring to the muscle membrane, in muscle development, neurogenesis and synapse formation.

Ankyrins are broadly expressed adaptors that organize diverse membrane proteins into specialized domains and link them to the sub-membranous cytoskeleton. In neurons, ankyrins are known to have essential roles in organizing the axon initial segment and nodes of Ranvier.

Recent data on characteristics of the structure, functions, and main properties of ankyrins (proteins that are linkers between the spectrin-based cytoskeleton and integral membrane proteins) are summarized. The interactions of ankyrins with band-3 protein, P-type ATPases, ion channels, receptors, and protein kinase C are considered.

Ankyrin-2, also known as Ankyrin-B, and Brain ankyrin, is a protein which in humans is encoded by the ANK2 gene. [2] [3] Ankyrin-2 is ubiquitously expressed, but shows high expression in cardiac muscle.

Dec 26, 2006 · Ankyrin repeat, one of the most widely existing protein motifs in nature, consists of 30-34 amino acid residues and exclusively functions to mediate protein-protein interactions, some of which are directly involved in the development of human cancer and other diseases.

Nov 24, 2020 · Ankyrins (Ank) are ubiquitously expressed proteins that play a critical role in the integrity of cytoskeleton and cellular signalling. Their presence in metazoans and evolutionary conserved protein primary sequence indicates their functional significance.

The meaning of ANKYRIN is any of a family of proteins that link spectrin in the cytoskeleton to proteins in the cell membrane and play a role in maintaining membrane stability —often followed by a number or a letter to indicate type. How to use ankyrin in a sentence.