Akt-mediated regulation of NFκB and the essentialness of NFκB …
Our data suggest that the stimulation of NFκB by Akt is dependent on the phosphorylation of p65 at S534, mediated by IKK (IκB kinase) α and β. Akt phosphorylates IKKα on T23, and this …
Stepwise phosphorylation of p65 promotes NF-κB activation …
May 25, 2016 · Synergistic signalling is defective in X-linked lymphoproliferative disease (XLP1) NK cells entailing 2B4 dysfunction and required for p65 phosphorylation by PI3K-Akt signal, …
Crosstalk between the Akt/mTORC1 and NF-κB signaling …
Jul 17, 2019 · In a rat model of HPH, we found that Akt/mTOR signaling was activated and the level of phosphorylated NF-κB (p65) was subsequently increased, indicating that crosstalk …
Critical roles of PI3K/Akt/NF‑κB survival axis in angiotensin II ...
Cells were treated with 10‑6 mol/l of Ang II and/or LY294002 (inhibitor of Akt) or 740Y‑P (activator of PI3K) for 48 h to detect Akt, phosphorylated (phospho)‑Akt, p65 NF‑κB, and phospho‑p65 …
Akt Suppresses Apoptosis by Stimulating the Transactivation Potential ...
Activated PI3K and Akt stimulate the p65 transactivation domain of NF-κB in a manner dependent on IκB kinase. (A) Akt requires IKKβ to activate NF-κB-dependent transcription.
Akt induces NF-κB activation by a phosphorylation cascade
May 1, 2008 · IKKα subunit in turn has an AKT consensus sequence, and we could show that it binds to both AKT and p65. Mutating the AKT consensus site of IKKα renders NF-κB …
Akt Is a Downstream Target of NF-κB - Journal of Biological Chemistry
The expression and phosphorylation of endogenous Akt is increased by p65. Expression of Akt driven off the CMV promoter was detected using an antibody against the Myc epitope tag. No …
Reduced cAMP, Akt Activation and p65-c-Rel Dimerization: …
Jul 14, 2011 · Our results demonstrate that mGluR3-induced cAMP reduction, Akt activation and p65-c-Rel interaction mediate the anti-apoptotic effect of mGluR3 agonists in NO-challenged …
Akt stimulates the transactivation potential of the RelA/p65 …
Jun 1, 2001 · Here we demonstrate that Akt targets the transactivation function of NF-kappaB by stimulating the transactivation domain of RelA/p65 in a manner that is dependent on IkappaB …
NF-κB stimulates Akt phosphorylation and gene ... - ScienceDirect
Oct 20, 2003 · Elevated expression of the NF-κB protein p65 stimulates Akt phosphorylation and increases transcription of the Akt gene [18]. We show that both actions of p65 on Akt are …