Here, we summarize the current knowledge about AhR signaling pathways, its ligands and AhR-mediated effects on cell specialization, host defense and detoxification. AhR-mediated health …

Mgta-456, an aryl hydrocarbon receptor (AHR) antagonist based expansion of CD34+ hematopoietic stem cells (HSC), permits selection of better HLA matched cord blood units …

Several studies indicate that murine and human HSC express modest AhR levels [98–100] and recent breakthrough studies indicate that the AhR plays a critical role in HSC growth and …

Oct 1, 2019 · In stem cell proliferation assay, compound 5b elicited marked HSC expansion. 1. Introduction. The aryl hydrocarbon receptor (AhR) is a transcription factor that belongs to a …

Jul 18, 2013 · Using a novel, pluripotent stem cell–based, chemically-defined, serum and feeder cell–free culture system, we show that the AhR is expressed in HPs and that, remarkably, AhR …

Jul 24, 2015 · Lack of aryl hydrocarbon receptor (AhR) has been associated with alterations in gene expression related to HSC function and the subsequent development of a …

Feb 15, 2004 · Our results demonstrate that C. elegans ahr-1 functions as a cell-type specific determinant. This study further supports the notion that the ancestral role of the AHR proteins …

Sep 10, 2010 · Mechanistic studies show that SR1 acts by antagonizing the aryl hydrocarbon receptor (AhR). The identification of SR1 and AhR modulation as a means to induce ex vivo …

Dec 7, 2017 · We have demonstrated that AHR antagonism is an effective strategy to expand functional HSCs and that novel small molecules inhibiting AHR can expand gene modified …

Sep 10, 2010 · Mechanistic studies show that SR1 acts by antagonizing the aryl hydrocarbon receptor (AHR). The identification of SR1 and AHR modulation as a means to induce ex vivo …