May 29, 2024 · AHCY is the gene that encodes the enzyme adenosylhomocysteinase. In mammals, AHCY is the only enzyme that can convert SAH to homocysteine, and it can also catalyze the reverse conversion of homocysteine to SAH. This makes it a key enzyme in a fundamental cellular pathway found in all animals.

Adenosylhomocysteinase (AHCY) is a unique enzyme and one of the most conserved proteins in living organisms. AHCY catalyzes the reversible break of S-adenosylhomocysteine (SAH), the by-product and a potent inhibitor of methyltransferases activity. ...

Adenosylhomocysteinase is an enzyme that converts S-adenosylhomocysteine to homocysteine and adenosine and is encoded for by the AHCY gene 1. AHCY is of interest due to its position in the methionine cycle, part of the wider methylation pathway .

Sep 1, 2017 · Using fluorescence microscopy and GFP-tagged AHCY constructs we show significant differences in the intensity ratio between nuclei and cytoplasm for mutant proteins when compared with wild type AHCY.

S-Adenosylhomocysteine hydrolase (AHCY) is the only mammalian enzyme known to catalyze the hydrolysis of S-adenosylhomocysteine (AdoHcy). We have used a genotype-to-phenotype strategy to study this important enzyme by resequencing AHCY in 240 DNA ...

The AHCY gene provides instructions for producing the enzyme S-adenosylhomocysteine hydrolase. This enzyme is involved in a multistep process that breaks down the protein building block (amino acid) methionine.

Mar 30, 2025 · AHCY (Adenosylhomocysteinase) is a Protein Coding gene. Diseases associated with AHCY include Hypermethioninemia With S-Adenosylhomocysteine Hydrolase Deficiency and Hypermethioninemia. Among its related pathways are L-methionine degradation I (to L-homocysteine) and Peptide chain elongation.

Nov 3, 2024 · Clinical resource with information about AHCY, Hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

The AHCY gene, encodes for the enzyme S-adenosylhomocysteine hydrolase (AHCY). This enzyme plays a crucial role in the metabolism of adenosine homocysteine (AHC), a byproduct of various metabolic pathways.

Mar 31, 2021 · In humans, AHCY deficiency is associated with an incurable rare recessive disorder in methionine metabolism. In this review, we focus on the AHCY protein from an evolutionary, biochemical, and...