Adiponectin (also referred to as GBP-28, apM1, AdipoQ and Acrp30) is a protein hormone and adipokine, which is involved in regulating glucose levels and fatty acid breakdown. [5] [6] In humans, it is encoded by the ADIPOQ gene and is produced primarily in adipose tissue, but also in muscle and even in the brain. [7] [8]

Mar 28, 2025 · ADIPOQ (Adiponectin, C1Q And Collagen Domain Containing) is a Protein Coding gene. Diseases associated with ADIPOQ include Adiponectin Deficiency and Prediabetes Syndrome. Among its related pathways are Epigenetic regulation by WDR5-containing histone modifying complexes and AMP-activated protein kinase signaling.

Adiponectin, an adipokine secreted by adipocytes, is a well-known homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity through its anti-inflammatory, anti-fibrotic, and antioxidant effects. All these metabolic processes are mediated via two adiponectin receptors, AdipoR1 and AdipoR2.

Jul 30, 2023 · Adiponectin (also known as AdipoQ or ACRP30) is a 244 amino acid monomer adipokine with a molecular weight of approximately 26 kDa. Adiponectin is the most abundant peptide hormone secreted by white adipocytes.

ADIPOQ gene (T45G and G276T) single nucleotide polymorphisms and their association with gestational diabetes mellitus in a Filipino population. STAT3 Signalling Drives LDH Up-Regulation and Adiponectin Down-Regulation in Cachectic Adipocytes.

Using an mRNA differential display technique, we have isolated a novel adipose cDNA, termed adipoQ. The adipoQ cDNA encodes a polypeptide of 247 amino acids with a secretory signal sequence at the amino terminus, a collagenous region (Gly-X-Y repeats), and a globular domain.

Adiponectin is the most abundant peptide secreted by adipocytes, whose reduction plays a central role in obesity-related diseases, including insulin resistance/type 2 diabetes and cardiovascular disease. In addition to adipocytes, other cell types, such as skeletal and cardiac myocytes and endothelial cells, can also produce this adipocytokine.

Sep 16, 2022 · Using the UK Biobank including data from over 500000 individuals, we examined a pleiotropic effect of the ADIPOQ variant by comparing CD- and AD/D-associated phenotypic evidence, including...

Feb 8, 2025 · ADIPOQ stimulates autophagic flux in skeletal muscle, which likely represents one important mechanism mediating multiple favorable metabolic effects; adiponectin is an important determinant of the kidney response to high glucose in vivo and in vitro

HGNC Approved Gene Symbol: ADIPOQ. Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38) : 3:186,842,710-186,858,463 (from NCBI) Adiponectin is a hormone secreted by adipocytes that regulates energy homeostasis and glucose and lipid metabolism.