A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS2) also known as procollagen I N-proteinase (PC I-NP) is an enzyme [4] that in humans is encoded by the …

The ADAMTS2 gene provides instructions for making an enzyme that processes several types of procollagen molecules. Learn about this gene and related health conditions.

Mar 28, 2025 · ADAMTS2 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 2) is a Protein Coding gene. Diseases associated with ADAMTS2 include Ehlers-Danlos Syndrome, …

ADAMTS (short for a disintegrin and metalloproteinase with thrombospondin motifs) is a family of multidomain extracellular protease enzymes. [1] 19 members of this family have been …

ADAMTS2 (A Disintegrin and Metalloproteinase With Thrombospondin Motifs 2) is recognized as a metalloproteinase that promotes the cleavage of amino propeptides of types I, II, III, and V …

Dec 10, 2024 · Go to complete Gene record for ADAMTS2; Go to Variation Viewer for ADAMTS2 variants; Summary. This gene encodes a member of the ADAMTS (a disintegrin and …

Pro-collagen I N-proteinase is now referred to as ADAMTS2. Furthermore, five ADAMTSL genes have recently been identified. These members lack the PD, MP and DIS domains found in …

May 1, 2015 · ADAMTS2 deficiency leads to the dermatosparactic type of Ehlers–Danlos syndrome. ADAMTS2 and 3 are regulators of blood vessels homeostasis and …

ADAMTS-2 is a metalloproteinase that plays a key role in the processing of fibrillar procollagen precursors into mature collagen molecules by excising the amino-propeptide.

As dramatically seen in the dermatosparactic type of EDS, ADAMTS2 is crucial for fibrillar collagen maturation. This largely explain why most of the studies about ADAMTS2, but also …