Long-chain-fatty-acid—CoA ligase 4 is an enzyme that in humans is encoded by the ACSL4 gene. [5] [6] [7] The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family.

Mar 30, 2025 · ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) is a Protein Coding gene. Diseases associated with ACSL4 include Intellectual Developmental Disorder, X-Linked 63 and Intellectual Disability, X-Linked 63. Among its related pathways are Fatty acid metabolism and Integration of energy metabolism.

ACSL4 is an enzyme involved in the intracellular conversion of long-chain fatty acids and coenzyme A into fatty-acid coenzymes. It plays a vital role in various biological processes, including maintaining cell membrane structure, energy metabolism, and lipid metabolism.

Jul 13, 2022 · Recently, acyl-CoA synthetase long-chain family 4 (ACSL4) is found be participated in the activation of long chain fatty acids metabolism, immune signaling transduction, and ferroptosis, which can be a promising potential target and biomarker for anticancer.

We applied two independent approaches-a genome-wide CRISPR-based genetic screen and microarray analysis of ferroptosis-resistant cell lines-to uncover acyl-CoA synthetase long-chain family member 4 (ACSL4) as an essential component for ferroptosis execution.

ACSL4 remodels the phospholipid composition of cell membranes, regulates steroidogenesis, and balances eicosanoid biosynthesis. In addition, ACSL4-mediated metabolic reprogramming and antitumor immunity have attracted much attention in cancer biology.

Mar 29, 2024 · ACSL4 contributes to ferroptosis by promoting the esterification of polyunsaturated fatty acids (PUFAs) to acyl-CoA, especially adrenic acid (C22:4) and AA (C20:4) . Therefore, ACSL4 is an important pharmacological target for ferroptosis in the treatment of ferroptosis-related diseases.

ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc/SREBP1 pathway. New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesis.

Nov 14, 2016 · We applied two independent approaches—a genome-wide CRISPR-based genetic screen and microarray analysis of ferroptosis-resistant cell lines—to uncover acyl-CoA synthetase long-chain family member 4...

Apr 7, 2025 · f ACSL4 protein levels were analyzed in paired adjacent and ESCC tissues. Data of (d and f) are shown as mean ± SD, and P value was determined by Mann–Whitney U test. g Relationship between ACSL4 protein levels and overall survival of patients in ESCC tissue microarray. P value was determined by Kaplan–Meier analysis.