IFI-16 inhibition attenuates myocardial remodeling following …
Aug 16, 2024 · In our investigation, we systematically examined the expression levels of IFI-16, apoptosis-associated Speck-like protein (ASC), pro-caspase-1, cleaved-caspase-1, gasdermin …
The KLF7/PFKL/ACADL axis modulates cardiac metabolic ... - Nature
Feb 21, 2023 · In this study, we reveal the critical transcriptional role of KLF7 in pathological cardiac hypertrophy and cardiac metabolism. We identified the rate-limiting enzyme for …
Astragaloside IV derivative HHQ16 ameliorates infarction-induced ...
Oct 19, 2023 · Here, we report a novel small molecule HHQ16, an optimized derivative of astragaloside IV, which effectively reversed infarction-induced myocardial remodeling and …
Urban fine particulate matter causes cardiac hypertrophy through ...
Jul 15, 2022 · WGA-FITC staining indicates the size of a single cell of AC16 (x200 scale bar 50 μm; E). The effect of PM 2.5 on the hypertrophic protein expression of ANP, BNP in AC16, …
Low‐intensity pulsed ultrasound improves myocardial ischaemia ...
Jul 4, 2024 · Here, we utilised low‐intensity pulsed ultrasound (LIPUS) on MIRI mice model and demonstrated that LIPUS reduced the infarcted area and improved cardiac dysfunction. …
The proteasome activator REGγ accelerates cardiac hypertrophy …
May 18, 2020 · Following CHX treatment for various periods of time, PP2Acα was degraded faster in REGγ-WT NRCMs or AC16 cells than in REGγ-knockdown NRCMs or AC16 cells (Fig. 4i–l).
METTL3 improves cardiomyocyte proliferation upon myocardial …
In AC16, Ad-METTL3 improved the hypoxia-stimulated decrease in myocardial proliferation and increase in apoptosis (Supplementary Fig. 2). In addition, si-METTL3 mimicked the …
Development of Magnetic Torque Stimulation (MTS) Utilizing …
By computationally optimizing the rotating magnetic field using COMSOL™ with two-dimensional (2D) finite element analysis (FEA), we built a highly uniform MTS system for remotely …
Targeting autophagy with SAR405 alleviates doxorubicin-induced ...
Sep 28, 2023 · Using the cardiomyocyte cell lines AC16 and H9c2, we determined that autophagy was initiated during AIC. Our results suggest that inhibition of autophagy at its early phase with …
Roles of AhR/CYP1s signaling pathway mediated ROS
May 15, 2024 · Wheat germ agglutinin (WGA) staining was carried out to label the cell membranes. The frozen heart sections were firstly fixed under 4% paraformaldehyde. After …