Mar 4, 2015 · In this study, we generated mice in which Bmal1 was deleted specifically in AVP neurons and analyzed circadian rhythms in behavior as well as in SCN cells and tissues.

Apr 15, 2021 · Several neuropeptides such as arginine vasopressin (AVP) and vasoactive intestinal polypeptide (VIP) are expressed in the SCN, where these neuropeptides function as synchronizers and are important for entrainment to environmental light and for determining the circadian period.

To achieve genetic manipulations specifically in AVP neurons, we generated a bacterial artificial chromosome (BAC) transgenic mouse that expressed codon-improved Cre recombinase (Shimshek et al., 2002) under the transcriptional control of Avp promoter (Avp-Cre mice).

Feb 17, 2020 · We identified notable phase differences in circadian gene expression with the Avp+ / Nms+ subtype in the dorsal SCN and the Vip+ / Nms+ subtype in the ventral SCN, and the phase-leading Cck+ /...

Nov 11, 2020 · Here, we identify ∼20% of all SCN neurons as “night active” by c-FOS staining; our single-cell sequencing suggests that these night-active SCN neurons are either avp+ nms+, and active during the early night (to ∼ZT16) or vip+ nms+ and active during the daily siesta toward the end of the night.

Sep 9, 2021 · AVP exerts negative control over basal plasma corticosterone (CORT) concentrations by inhibiting the secretion of CRH macroscopically, resulting in a precise systemic circadian pattern with GCs...

Apr 15, 2021 · Several neuropeptides such as arginine vasopressin (AVP) and vasoactive intestinal polypeptide (VIP) are expressed in the SCN, where these neuropeptides function as synchronizers and are important for entrainment to environmental light and for determining the circadian period.

Arginine vasopressin (AVP) is a neurohormone that alters cellular physiology through both endocrine and synaptic signaling. Circadian rhythms in AVP release and other biological processes are driven by the suprachiasmatic nucleus (SCN) of the anterior hypothalamus.

Feb 25, 2019 · The characterization of Avp-Bmal1-/-mice and Avp-CK1δ-/-mice definitively demonstrated that cellular clocks of SCN AVP neurons play a critical role in the generation of robust circadian behavior rhythm through the regulation of the coupling of SCN neurons, as well as in the determination of the circadian period. Additional manipulations of ...

To examine the roles of Arg-vasopressin (AVP)- and vasoactive intestinal peptide (VIP)-containing neurons in the suprachiasmatic nucleus (SCN) in production of circadian rhythmicity of locomotor activity, variations in the contents of AVP and VIP in punched-out …