May 26, 2020 · Recently, there is accumulating evidence showing that some ATG proteins have the ability to directly interact with membranes, transfer lipids between membranes and regulate lipid metabolism....

In this review we describe the molecular mechanism of autophagosome formation with particular focus on the function of Atg proteins and the long-standing discussion regarding the origin of the autophagosome membrane.

Autophagy-related protein 8 (Atg8) is a ubiquitin-like protein required for the formation of autophagosomal membranes. The transient conjugation of Atg8 to the autophagosomal membrane through a ubiquitin -like conjugation system is essential for autophagy in eukaryotes.

Autophagy‐independent roles of the ATG proteins include the maintenance of cellular homeostasis and resistance to pathogens. For example, they assist and enhance the turnover of dead cells and microbes upon their phagocytic engulfment, and …

Autophagy occurs at basal levels in any cell to carry out the proper degradation of long-lived proteins, protein aggregates or damaged organelles, ultimately ensuring cellular homeostasis. However, different stress conditions can cause the active induction of the autophagic machinery.

Sep 18, 2015 · Labels in green boxes indicate core ATG proteins required for autophagosome formation. A growing body of evidence suggests that autophagy has important roles in various biological processes at...

In this review, we present our views of the key features of the Atg8-proteins and describe the basic principles of their recognition and binding by interaction partners.

May 26, 2020 · Recently, there is accumulating evidence showing that some ATG proteins have the ability to directly interact with membranes, transfer lipids between membranes and regulate lipid metabolism. A novel role for various membrane lipids in …

Apr 9, 2025 · The transmembrane autophagy protein ATG9 has multiple functions essential for autophagosome formation. Here, we uncovered a novel function of ATG-9 in regulating lysosome biogenesis and integrity in Caenorhabditis elegans. Through a genetic screen, we identified that mutations attenuating the lipid …

Apr 2, 2025 · Atg11 plays a role in high-fidelity chromosome transmission. To understand the role of autophagy protein(s) in the cell cycle in nutrient-rich conditions, we carried out a phenotypic screen to determine the growth fitness of null mutants of autophagy-related genes (atg) in S. cerevisiae to a MT depolymerizing drug, thiabendazole (TBZ).Among all the 35 atg mutants (), atg11∆ cells displayed ...