Feb 23, 2001 · Here we show that in vitro binding of AP2 to sorting signals, which is one of the initial steps in receptor-mediated endocytosis, is modulated by adaptor phosphorylation. AP2 …

Feb 23, 2001 · Here we show that in vitro binding of AP2 to sorting signals, which is one of the initial steps in receptor-mediated endocytosis, is modulated by adaptor phosphorylation. AP2 …

We propose that phosphorylation of the AP2 μ2 subunit by AAK1 ensures high affinity binding of AP2 to sorting signals of cargo membrane proteins during the initial steps of receptor …

The best-characterized sorting signals are tyrosine-based (YXXØ) and dileucine-based ([DE]XXXL[LI]) signals (X is any amino acid and Ø is a bulky hydrophobic amino acid, i.e. …

Via a tyrosine-based sorting motif YXXΦ in their cytoplasmic tails, they link the bound cargo to the cellular adapter protein-2 (AP2), thereby sorting it into clathrin-triskelion-coated pits for …

AP2 in synaptic vesicle endocytosis. The clathrin adaptor protein complex AP2 is a major protein–protein interaction hub that coordinates cargo sorting, accessory protein binding, and …

Here we show that in vitro binding of AP2 to sorting signals, which is one of the initial steps in recep-tor-mediated endocytosis, is modulated by adaptor phosphorylation. AP2 was …

Mar 1, 2001 · Here we show that in vitro binding of AP2 to sorting signals, which is one of the initial steps in receptor-mediated endocytosis, is modulated by adaptor phosphorylation. AP2 …

AP2 has been shown to bind to protein cargo through Yxxf-sorting motifs via the C-terminal subdo- main of its 2 subunit (C- 2, residues 157–435) (Ohno et al., 1995; Owen and Evans, …

May 27, 2005 · Recent studies on the function of AP2 have demonstrated that phosphorylation of the AP2 μ2 subunit modulates its function, with phosphorylation being a trigger for high-affinity …