Angiopoietin-like 3, also known as ANGPTL3, is a protein that in humans is encoded by the ANGPTL3 gene. [5][6] The protein encoded by this gene is a member of the angiopoietin -like …

Jan 6, 2021 · Quick Takes New therapies targeting ANGPTL3 can significantly reduce LDL cholesterol and triglycerides. ANGPTL3 therapies have the potential to reinforce the current …

May 29, 2024 · Angiopoietin-like 3 (ANGPTL3) inhibits lipoprotein and endothelial lipases and hepatic uptake of triglyceride-rich lipoprotein remnants. ANGPTL3 loss-of-function carriers …

Angiopoietin-like protein 3 (ANGPTL3) belongs to a multifunctional secreted protein that mainly expresses in the liver, and is regulated by numerous post-translational modifications, including …

Jul 20, 2017 · Loss-of-function variants in the angiopoietin-like 3 gene (ANGPTL3) have been associated with decreased plasma levels of triglycerides, low-density lipoprotein (LDL) …

Feb 22, 2024 · ANGPTL3 (angiopoietin-like protein 3) is a circulating protein with a key role in maintaining lipoprotein homeostasis. A monoclonal antibody against ANGPTL3 is an approved …

Angiopoietin-like protein (ANGPTL)3 regulates plasma lipids by inhibiting LPL and endothelial lipase (EL). ANGPTL3 inactivation lowers LDL-C independently of the classical LDLR …

Oct 6, 2017 · Three members of the angiopoietin-like (ANGPTL) protein family — ANGPTL3, ANGPTL4 and ANGPTL8 — have emerged as important regulators of plasma lipoprotein …

Jun 14, 2017 · Genetic and preliminary intervention studies published in two papers in NEJM indicate that angiopoietin-related protein 3 (ANGPTL3) is a promising therapeutic target in …

Mar 28, 2025 · ANGPTL3 (Angiopoietin Like 3) is a Protein Coding gene. Diseases associated with ANGPTL3 include Hypobetalipoproteinemia, Familial, 2 and Developmental And Epileptic …