May 28, 2021 · We are conducting a first-in-human phase 1 study with AMG 650 in adult subjects with locally advanced or metastatic solid tumors with TP53MUT, triple negative breast cancer (TNBC), high grade serous ovarian cancer (HGSOC) …

chromosomal instability (CIN). AMG 650 is a selective inhibitor of KIF18A that phenocopies the effects observed for KIF18A knockdown. Osteosarcoma is characterized by a chaotic genome with chromothripsis and a large number of chromosomal structural variants, and …

Jan 24, 2024 · To substantiate the therapeutic utility of KIF18A inhibitors, the drug candidates sovilnesib (AMG 650) and VLS-1488 have entered early clinical testing 5,6. The KIF18A inhibitors described in...

Jun 2, 2022 · Discovery of potent, orally active KIF18A inhibitors targeting CIN-high cancer cells. Bedside to benchtop translational development: Targeting the S1P/ceramide axis may alleviate symptoms of chemical induced peripheral neuropathy. Mechanisms of anticancer activity of bacteria in enhancing cancer immunotherapy. e15046.

Apr 4, 2023 · Here, we report the discovery and preclinical characterization of AMG 650, a potent and selective inhibitor of KIF18A with a compelling anti-cancer profile distinct from other cell cycle and anti-mitotic drug targets.

May 19, 2021 · amg 650 Trial-in-Progress: A Phase 1, Multicenter, Open-Label, Dose-Exploration and Dose-Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 650 in Subjects with Advanced Solid Tumors

KIF18A is a mitotic kinesin that plays a key role in maintaining bipolar spindle integrity and promotes viability of chromosomally unstable aneuploid cancer cells. KIF18A is overexpressed in a subset of cancers, and its elevated expression is …

Mar 2, 2020 · A Phase 1, Multicenter, Open-label, Dose-Exploration and Dose-Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of AMG 650 in Subjects With Advanced Solid Tumors.

Discovery of AMG 650, a first-in-class KIF18A inhibitor for the treatment of chromosomally unstable cancers (ACS-Sp 2022) - "AMG 650 binds to the complex formed by the motor domain of KIF18A and tubulin, exploiting unique interactions in this ternary complex. AMG 650 has advanced to Phase I clinical testing in patients with advanced solid ...

Brief Title: Study of AMG 650 in Adult Participants With Advanced Solid Tumors; Official Title: A Phase 1, Multicenter, Open-label, Dose-Exploration and Dose-Expansion Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy …