A-431 is a cell line exhibiting epithelial morphology that was isolated from the epidermis of an 85-year-old female patient with epidermoid carcinoma. This cell line is one of a series of cell lines established from solid tumors by D.J. Giard, et al. and can be used in cancer, toxicology, and immuno-oncology research.

A431 cells are used in studies of the cell cycle and cancer-associated cell signalling pathways since they express abnormally high levels of the Epidermal growth factor receptor (EGFR). They are often used as a positive control for EGFR expression.

A431 cells overexpress epidermal growth factor receptor (EGFR). They serve as a positive control for studying EGFR signalling and its implications in cancer. They are also used to evaluate new cancer therapies.

Culture of A-431 human epidermoid carcinoma cells in serum-free medium: effect of culture conditions on the binding of [125I]-epidermal growth factor. Different responses to EGF in two human carcinoma cell lines, A431 and UCVA-1, possessing high numbers of EGF receptors.

Sep 3, 2021 · S7 ADC treatment induced much higher apoptosis of A431 and MDA-MB-468 cells and triggered a substantial dose-dependent shift of tumor cell cycle from G1 phase to G2/M phase with respect to 97m ...

A431 is a human epidermoid carcinoma cell line that was originally derived from a skin biopsy of a patient with vulvar squamous cell carcinoma. It is commonly used as a model for studying the biology of epithelial cancers, particularly those of the skin and mucous membranes.

The A-431 cell line, which was derived from an epidermoid carcinoma excised from the skin tissue of an 85-year-old female, is one of a succession of cell lines established from solid tumors by a research team led by D. J. Giard.

Nov 30, 2012 · In this study, we attempt to elucidate the global protein expression and functional changes in A431 epithelial carcinoma cells induced by hypoxia and reoxygenation using iTRAQ quantitative proteomics and biochemical functional assays.

The epidermoid carcinoma cell line A431 expresses abnormally high levels of epidermal growth factor receptor (EGFR) and is a useful model for studying EGFR-mediated signaling, which regulates growth, survival, proliferation, and differentiation in mammalian cells.

STR analysis according to the global standard ANSI/ATCC ASN-0002.1-2021 (2021) resulted in an authentic STR profile of the reference STR database.