Jun 10, 2008 · Crystal structures of caspase-3 in complexes with isoquinoline-1,3,4-trione derivatives show that the catalytic cysteine is oxidized to sulfonic acid (-SO (3)H) and isoquinoline-1,3,4-trione derivatives are bound at the dimer interface of caspase-3.

Oct 31, 2008 · Caspase-3 is an attractive therapeutic target for treatment of diseases involving disregulated apoptosis. We report here the mechanism of caspase-3 inactivation by isoquinoline-1,3,4-trione derivatives.

Molecular Components in 3DEH; Label Count Molecule; Proteins (2 molecules) A. B. 2: Caspase-3 (Gene symbol: CASP3) Chemical and Non-standard biopolymers (1 molecule) 1. 1. Isoquinoline-1,3,4(2h)-Trione * Click molecule labels to …

3DEH: Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors

Sep 2, 2008 · 3deh: Isoquinoline-1,3,4-trione derivatives inactivate caspase-3 by generation of reactive oxygen species.

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3deh is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. …

Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors

PDB entry 3deh View 3deh on RCSB PDB site Description: Crystal Structures of Caspase-3 with Bound Isoquinoline-1,3,4-trione Derivative Inhibitors Class: Hydrolase, Apoptosis

PDB Entry: 3deh (more details), 2.5 Å PDB Description : crystal structures of caspase-3 with bound isoquinoline-1,3,4-trione derivative inhibitors PDB Compounds : (A:) Caspase-3