We calculated means and standard deviations of genomic representation (GR) in the tested chromosome (GR_chrN) of the reference controls and computed a count-based Z-score for each chromosome in each test sample using the following equation : Count-based Z-score_chrN = (GR_chrN_sample - mean GR_chrN_ref)/SD GR_chrN_ref.

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Current NIPT for fetal chromosomal disorders are based on the counting of DNA molecules in maternal plasma. Here, we show that plasma DNA-based molecular diagnostics can also be built around DNA fragment size, instead of count.

Jan 4, 2015 · It can be a boy or girl. That's normal range for either sex at this stage. Looking back in their baby books my DS1 and DS2's heart rates were 161 and 165 at 16 weeks x

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ple - mean GR_chrN_ref)/SD GR_chrN_ref. Figure 1. Detection of fetal trisomy 13 using the traditional count-based Z-scores and count-based Z-scores with 100-, 130-, 150-, and 166-bp size cor - rection. Dashed lines indicate Z-score cutoffs. Figure 2. Detection of fetal trisomy 18 using the traditional count-based Z-

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