Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene. [5] It is the only known protein to contain the unusual amino acid hypusine [N ε-(4-amino …

Mar 28, 2025 · EIF5A (Eukaryotic Translation Initiation Factor 5A) is a Protein Coding gene. Diseases associated with EIF5A include Faundes-Banka Syndrome and Non-Specific …

Dec 17, 2022 · Here we show that the function of the elongation factor, eIF5a, is regulated dynamically in naïve CD8 + T cells upon activation by post-translational modification, …

Since the demonstration of its involvement in cell proliferation, the eukaryotic initiation factor 5A (eIF5A) has been studied principally in relation to the development and progression of cancers …

Apr 20, 2017 · Using a combination of ribosome profiling and in vitro biochemistry, we report a much broader role for eIF5A in elongation and uncover a critical function for eIF5A in …

eIF5A has been shown to regulate a number of gene products specifically, termed the eIF5A regulon, and its role in translating proline-rich sequences has recently been identified. eIF5A …

Dec 1, 2024 · Among these factors, eukaryotic translation initiation factor 5 A (eIF5A) emerges as a crucial translation factor with high evolutionary conservation. eIF5A is unique as it is the only …

The eukaryotic translation initiation factor 5A (eIF5A) is a highly conserved protein and is essential in all eukaryotes. However, the specific roles of eIF5A in translation and in other biological …

Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.

Dec 12, 2022 · Overexpression of eIF5A has been linked with the development of a variety of cancers and inhibitors of the molecule have been proposed for anti-cancer clinical …