Mar 28, 2025 · EIF5 (Eukaryotic Translation Initiation Factor 5) is a Protein Coding gene. Diseases associated with EIF5 include Fibroosseous Pseudotumor Of Digits and Mehmo …

PDBe-KB provides an overview of all the structure information available in the PDB for Human Eukaryotic translation initiation factor 5 (EIF5)

Eukaryotic translation initiation factor-5 (EIF5) interacts with the 40S initiation complex to promote hydrolysis of bound GTP with concomitant joining of the 60S ribosomal subunit to the 40S …

Sep 2, 2014 · eIF5 is the GTPase activating protein (GAP) for the eIF2·GTP·Met-tRNA iMet ternary complex with a critical role in initiation codon selection. Previous work suggested that …

The translation factor eIF5 is an important partner of eIF2, directly modulating its function in several critical steps. First, eIF5 binds eIF2/GTP/Met-tRNA(i)(Met) ternary complex (TC), …

Dec 24, 2021 · Since the demonstration of its involvement in cell proliferation, the eukaryotic initiation factor 5A (eIF5A) has been studied principally in relation to the development and …

Increased phosphorylation of eIF2 under amino acid starvation conditions leads to a corresponding increase in GCN4 mRNA translation. The carboxyl-terminal domain (CTD) of …

Apr 11, 2006 · Eukaryotic initiation factor 5 (eIF5) plays multiple roles in translation initiation. Its N-terminal domain functions as a GTPase-activator protein (GAP) for GTP bound to eIF2, …

Nov 26, 2018 · The N-terminal domain (NTD) of the initiation factor eIF5 bound to the 40S subunit at the precise location vacated by eIF1 promotes tRNAi accommodation at AUG codons.

Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene. [5] It is the only known protein to contain the unusual amino acid hypusine [Nε - (4 …