Eukaryotic translation initiation factor 4 G (eIF4G) is a protein involved in eukaryotic translation initiation and is a component of the eIF4F cap-binding complex. Orthologs of eIF4G have been …

Inhibiting expression of eukaryotic translation initiation factor 4G (eIF4G) arrests normal development but extends lifespan when suppressed during adulthood. In addition to reducing …

Mar 28, 2025 · EIF4G1 (Eukaryotic Translation Initiation Factor 4 Gamma 1) is a Protein Coding gene. Diseases associated with EIF4G1 include Parkinson Disease 18, Autosomal Dominant …

Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene. [5][6] The protein encoded by this gene is a component of the protein complex …

The mRNA is circularized by interactions between eIF4G and the poly-A-binding protein (PABP, purple). eIF4G facilitates recruitment of the 40S ribosomal subunit (light gray, in mammals via …

May 2, 2024 · The heat shock response is crucial for cell survival. In this issue of Molecular Cell, Desroches Altamirano et al. demonstrate that a temperature-induced conformational change in …

Aug 31, 2019 · We discovered that alteration frequency in EIF4G1 is prevalent in human cancers e.g. prostate cancer (~ 25%), ovarian cancer (~ 15%), Head and Neck cancer (~ 13%) and …

In mammals, the direct interaction between eukaryotic initiation factor 4G (eIF4G) and eIF3 is thought to act as the molecular bridge between the mRNA cap-binding complex and the 40S …

Jun 20, 2023 · The eIF4F complex, composed of the cap-binding protein eIF4E, ATP-dependent RNA helicase eIF4A, and scaffolding protein eIF4G, is a pivotal factor in the mRNA translation …

Oct 14, 2014 · eIF4G is a scaffold protein around which mRNA, ribosomal subunits and the cap-binding complex assemble in order to accomplish translation. There is evidence for the …