eIF2B - Wikipedia
eIF2B is a protein complex found in eukaryotes. It is the guanine nucleotide exchange factor for the eukaryotic initiation factor 2 and therefore converts the inactive eIF2- GDP to the active …
eIF2B and the Integrated Stress Response: a structural and …
Here, we discuss the recent reports on the structure, function, and regulation of eIF2B; the pre-clinical data on the use of ISR inhibitors for treatment of neurodegenerative disorders; and …
eIF2B Mechanisms of Action and Regulation: A Thermodynamic …
Eukaryotic translation initiation factor 2B (eIF2B) is the guanine nucleotide exchange factor of the GTPase eIF2, which brings the initiator Met-tRNA i to the ribosome in the form of the eIF2 …
eIF2B activator prevents neurological defects caused by a chronic ...
Jan 9, 2019 · Vanishing White Matter (VWM) is a neurological disease caused by eIF2B mutations that, like phosphorylated eIF2, reduce its activity. We show that introduction of a …
eIF2B: recent structural and functional insights into a key
The eukaryotic translation initiation factor (eIF) eIF2B is a key regulator of mRNA translation, being the guanine nt exchange factor (GEF) responsible for the recycling of the heterotrimeric …
The structural basis of translational control by eIF2 ... - Nature
May 13, 2019 · To provide insight into the mechanism of translational control we have determined the structures of eIF2 both in phosphorylated and unphosphorylated forms bound with its …
Structural basis for eIF2B inhibition in integrated stress response
May 3, 2019 · To elucidate how the eIF2 phosphorylation status regulates the eIF2B activity, we determined cryo–electron microscopic and crystallographic structures of eIF2B in complex with …
A helical fulcrum in eIF2B coordinates allosteric regulation
Nov 9, 2023 · Using hydrogen–deuterium exchange–mass spectrometry and cryo-electron microscopy, we identified a central α-helix whose orientation allosterically coordinates eIF2B …
A new function and complexity for protein translation initiation …
eIF2B is a multisubunit protein that is critical for protein synthesis initiation and its control. It is a guanine nucleotide exchange factor (GEF) for its GTP-binding protein partner eIF2. eIF2 binds …
Architecture of the eIF2B regulatory subcomplex and its …
Nov 11, 2015 · Eukaryal translation initiation factor 2B (eIF2B) acts as guanine nucleotide exchange factor (GEF) for eIF2 and forms a central target for pathways regulating global …