Mar 3, 2012 · A tosyl group is defined as a substitution at the C-4 position of a coumarin ring, which enhances antiproliferative activity and can act as a potential inhibitor of heat shock protein 90. AI generated definition based on: Advances in Structure and Activity Relationship of Coumarin Derivatives , 2016

Oct 5, 2023 · Hydrochlorination of alkenes (72) is achieved using a combination of p-tosyl chloride and phenylsilane in the presence of cobalt catalyst, Scheme 29 [46]. Here, p-tosyl chloride and phenylsilane are served as a source of chlorine and hydrogen atom, respectively. This reaction condition showed high regioselectivity and afforded Markovnikov's ...

The tosyl group on the starting material is displaced by thiomethoxide by refluxing methyl 2,3-O-isopropylidene-5-O-p-tolylsulfonyl-β-d-ribofuranoside (2; 500 mg, 1.4 mmol) and 4 equivalents of sodium thiomethoxide (400 mg, 5.6 mmol) in DMF overnight.

Oct 5, 2023 · Alternatively, it is called p-tosyl chloride and abbreviated as p-TsCl or TsCl [1]. The chemical properties of p-TsCl are almost parallel with an acid halide [2]. Fig. 1 represents the chemical structure of p-toluenesulfonyl chloride.

Jan 18, 2017 · Tosyl chloride can also be removed by its reaction with primary or secondary amines. 2 In this case the tosyl amides must be removed from solution. Finally tosyl chloride can be removed from solution by its reaction with a second excess hydroxyl source in the presence of a base. The second alcohol is tosylated and then removed from the solution.

Oct 12, 2016 · Like sulfonamides, sulfonic esters also display important pharmacological activities. 7 Besides that, though synthetically these tosyl derivatives serve in different ways, masking of many functional groups 8 and as alkylating agents under SN reactions 9 are a couple of fundamental applications in organic chemistry therefore synthesis of ...

Tosyl lysine chloromethyl ketone (TosLysCH 2 Cl) was obtained from Sigma Chemical Co. (St. Louis MO) and tosyl leucine chloromethyl ketone (TosLeuCH 2 Cl) from Vega Biochemicals (Tucson AZ). The leucine derivative was first dissolved in 0.1 ml 100% ethanol prior to the addition of medium and diluted in medium containing an identical (0.15% or ...

Aug 1, 2014 · The method, termed the ligand-directed tosyl (LDT) chemistry [11 ••], allows selective chemical labeling of native proteins in various biological settings ranging from in vitro (in test tubes) to in cells and in vivo. The labeled native proteins are functional, and thus can be used for subsequent applications such as drug screening and imaging.

Jun 20, 2012 · Tosyl celluloses can be prepared by homogeneous derivatization in mixtures of ionic liquids and a co-solvent. Reaction time, molar ratio, and type of base determine the properties of the products obtained. NMR- and FT-IR spectroscopy as well as SEC were used to characterize tosyl celluloses with DS tosyl ≤ 1.14 and DS Cl ≤ 0.16. Tosyl- and chloro-deoxy …

Sep 10, 2013 · The MBC particles were then activated with p-toluenesulfonyl chloride to yield tosyl-activated magnetic bead cellulose (MBC-Ts). The microspheres were characterized by light and electron microscopy, elemental analysis and atomic absorption spectroscopy to determine morphology, size, polydispersity and content of iron and tosyl groups. The ...