Ras-related protein Rab-8A is a protein that in humans is encoded by the RAB8A gene. [5][6][7] The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids.

Rab8 localizes on primary cilia and has been shown to be required for ciliogenesis in cultured cells and a zebrafish model [128, 129], but not in mice . Taken together, Rab8 and Rab23 seem not to be essential for ciliogenesis itself, but to be likely to regulate ciliary functions in mammals.

Small GTP-binding proteins of the rab family have been implicated as regulators of membrane traffic along the biosynthetic and endocytic pathways in eukaryotic cells. We have investigated the localization and function of rab8, closely related to the yeast YPT1/SEC4 gene products.

Rab GTPases, which form the largest branch of the Ras GTPase superfamily, regulate almost every step of vesicle-mediated trafficking. Among them, Rab8 is an essential participant in primary cilium formation. In a report recently published in the ...

Jun 27, 2007 · Here we show that Rab8 is responsible for the localization of apical proteins in intestinal epithelial cells. We found that apical peptidases and transporters localized to lysosomes in the small...

Here, we have addressed the role of Rab8 (for which there are two isoforms Rab8a and Rab8b), a small GTPase implicated in ciliogenesis, in TCR traffic to the immune synapse. We show that Rab8, which colocalizes with IFT20 in Rab11 + endosomes, is required for TCR recycling.

Jan 1, 2018 · This review presents a synopsis of recent developments on Rab8 function. As detailed in the following sections, Rab8 regulates transport from the trans-Golgi network to the basolateral plasma membrane of epithelia, neuronal dendrites, and the ciliary membrane. Rab8 is required in cellular polarization, cellular signaling and development.

Feb 5, 2024 · Here, we show that deregulated RAB-8 activity resulted in impaired apical UcPS, which increased sensitivity to infection and environmental stress. We also identified the SNARE VTI-1/Vti1a/b as a new RAB-8-interacting factor involved in the apical UcPS.

Jul 15, 2014 · We discover that the small GTPase Rab8a is enriched in these ruffles and recruits phosphatidylinositol 3-kinase (PI3Kγ) as an effector by interacting directly through its Ras-binding domain....

Nov 26, 2024 · The Rab11-Rab8 cascade mediated by the Rab8 guanine nucleotide exchange factor (GEF), Rabin8, orchestrates multiple membrane transport processes, but Rab membrane loading and exchange dynamics are unclear. Here, we use advanced fluorescence imaging approaches to characterize Rab11, Rab8, and Rabin8 protein dynamics.