Regulator of G-protein signaling 14 (RGS14) is a protein that in humans is encoded by the RGS14 gene. [5] RGS14 is a member of the regulator of G protein signalling family. This protein …

Mar 30, 2025 · RGS14 (Regulator Of G Protein Signaling 14) is a Protein Coding gene. Diseases associated with RGS14 include Nephrolithiasis and Focal Epilepsy . Among its related …

In cells, RGS14 facilitates the formation of a selective Ras.GTP-Raf-MEK-ERK multiprotein complex to promote sustained ERK activation and regulate H-Ras-dependent neuritogenesis. …

RGS14 is a highly unusual complex family member that contains a canonical RGS domain, a tandem (R1 and R2) Ras/Rap binding domain (RBD) [5, 6], and a GoLoco/GPR (GL) motif. …

Feb 8, 2025 · RGS14 regulates PTH- and FGF23-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding protein. Human genetic variants disrupt RGS14 …

RGS14 regulates hormone-sensitive NPT2A-mediated renal phosphate uptake via binding to the NHERF1 scaffolding protein. 14-3-3γ binds RGS14 at distinct sites to inhibit the RGS14:Gαi …

Feb 1, 2013 · RGS14 possesses an RGS domain that binds active Gα(i/o)-GTP subunits to promote GTP hydrolysis and a G protein regulatory (GPR) motif that selectively binds inactive …

Here, we validate the specificity of a new polyclonal RGS14 antibody that recognizes not only full length RGS14 protein in primate, but also lower molecular weight forms of RGS14 protein …

Mouse RGS14 encodes a 547-amino-acid protein with an N-terminal RGS domain, which is highly expressed in lymphoid tissues. In this study, we demonstrate that RGS14 is a GAP for Giα …

RGS14 preferentially interacts with activated H-Ras in cells. We examined the capacity of RGS14 to interact with Ras proteins in mammalian cell co-immunoprecipitation (co-IP) assays.