Regulator of chromosome condensation 1, also known as RCC1, Ran guanine nucleotide exchange factor and RanGEF, is the name for a human gene and protein. [5] RCC1 also functions as a guanine nucleotide exchange factor for Ran GTPase.

Mar 30, 2025 · RCC1 (Regulator Of Chromosome Condensation 1) is a Protein Coding gene. Diseases associated with RCC1 include Raynaud Disease and Retinitis Pigmentosa 3. Among its related pathways are Transport of the SLBP independent Mature mRNA and HIV Life Cycle.

Aug 1, 2008 · The Regulator of Chromosome Condensation 1 (RCC1) was identified over 20 years ago as a critical cell cycle regulator. By analyzing its amino acid sequence, RCC1 was found to consist of seven homologous repeats of 51–68 amino acid residues, which were later shown to adopt a seven-bladed β-propeller fold.

Aug 25, 2010 · Here we determine the crystal structure of a complex of Drosophila RCC1 and the nucleosome core particle at 2.9 Å resolution, providing an atomic view of how a chromatin protein interacts with...

A review of the function and structure of RCC1 and RCC1 superfamily genes and proteins. These results show that human RCC1 isoforms have distinct chromatin binding properties, different molecular interactions, and are selectively regulated by …

Feb 28, 2022 · RCC1 (regulator of chromosome condensation 1) is a highly conserved chromatin-binding protein and the only known guanine-nucleotide exchange factor of Ran (a nuclear Ras homolog).

Here we report that protein arginine methyltransferase (PRMT) 6 activity is required for the proliferation, stem-like properties, and tumorigenicity of glioblastoma stem cells (GSCs), a subpopulation in GBM critical for malignancy.

Sep 15, 2020 · RCC1 (regulator of chromosome condensation 1) is the only known guanine nucleotide exchange factor of Ran, a nuclear Ras-like G protein. RCC1 combines with chromatin and Ran to establish a concentration gradient of RanGTP, thereby participating in a series of cell physiological activities.

The RCC1 gene, a regulator for the onset of chromosome condensation was found to encode a protein with a molecular mass of 45 kD, determined using the antibody against the synthetic peptides prepared according to the amino acid sequence of the putative RCC1 protein.

Here, we review the available structural and functional data on RCC1 superfamily members, paying special attention to the human proteins and their involvement in disease. The Regulator of Chromosome Condensation 1 (RCC1) was identified over 20 years ago as a …