Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. [5] [6] The Prox1 gene is critical for the development of multiple tissues. Prox1 activity is necessary and sufficient to specify a lymphatic endothelial cell fate in endothelial progenitors located in the embryonic veins. [7]

Mar 30, 2025 · PROX1 (Prospero Homeobox 1) is a Protein Coding gene. Diseases associated with PROX1 include Lymphangioma and Generalized Lymphatic Anomaly. Among its related pathways are Epithelial to mesenchymal transition in colorectal cancer and PTF1A related regulatory pathway.

Feb 13, 2025 · Our findings provide evidence for PROX1 as a hepatocyte-specific safeguard and support a model where cell-type-specific repressors actively suppress plasticity throughout life to safeguard...

PROX1 is a prognostic marker in Thyroid carcinoma Cancer specificity i Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected.

The human PROX1 gene (Prospero homeobox gene 1) is a member of the homeobox transcription factor family. PROX1 plays a key role in the development of the lymphatic system and is primarily used as a lymphatic vessel marker.

Jun 26, 2012 · PROX1 is a transcriptional regulator involved in neurogenesis, as well as in a variety of cancer types. Alterations in PROX1 expression have been reported in several cancer forms, although it is not always clear whether PROX1 exerts …

The homeobox gene Prox1, the vertebrate homologue of the Drosophila prospero gene, has been recently identified to be required for the induction of lymphatic vascular development from preexisting embryonic veins, and studies in Prox1-deficient mice have confirmed Florence Sabin's original hypothesis about the origin of the lymphatic vascular ...

Feb 8, 2025 · Title: Prox1 Suppresses Proliferation and Drug Resistance of Retinoblastoma Cells via Targeting Notch1. PROX1 interaction with alpha-SMA-rich cancer-associated fibroblasts facilitates colorectal cancer progression and correlates with poor clinical outcomes and therapeutic resistance.

PROX1 is a regulator of neuroendocrine-related gene expression in lung carcinoid. PROX1 drives neuroendocrine plasticity and liver metastases in prostate cancer. Prox1 Suppresses Proliferation and Drug Resistance of Retinoblastoma Cells via Targeting Notch1.

Oct 12, 2016 · Here we show that the transcription factor Prox1 is an important regulator of myoblast differentiation and of slow muscle fibre type. In both rodent and human skeletal muscles Prox1 is...