Feb 14, 2022 · Here we report a small molecule called CQ31 that selectively activates CARD8. CQ31 inhibits the M24B aminopeptidases prolidase (PEPD) and Xaa-Pro aminopeptidase 1 (XPNPEP1), leading to the...

Feb 1, 2023 · We recently reported that a dual inhibitor of the Xaa-Pro-cleaving M24B aminopeptidases PEPD and XPNPEP1 called CQ31 selectively activates the CARD8 inflammasome by inducing the build-up of Xaa-Pro peptides.

Feb 14, 2022 · A new paper reveals that inhibition of M24B aminopeptidases drives the selective activation of the CARD8 inflammasome, providing new insights into its regulation.

M24B peptidases cleaving Xaa-Pro bond in dipeptides are prolidases whereas those cleaving this bond in longer peptides are aminopeptidases-P. Bacteria have small aminopeptidases-P (36-39 kDa), which are diverged from canonical aminopeptidase-P of Escherichia coli (50 kDa).

This entry represents the cataltyic core of a group of metallopeptidases belong to MEROPS peptidase family M24 (clan MG), subfamily M24B. A number of different enzymes from various sources have the proline dipeptidase domain.

In this Article we identify and characterize M24B aminopeptidase inhibitors, which induce the accumulation of proline-containing peptides that weakly inhibit DPP8/9 as selective activators of the CARD8 inflammasome.

Peptidase family M24 contains exopeptidases that require co-catalytic ions of cobalt or manganese. Family M24 is one of a number of metallopeptidase families that are described as being co-catalytic.

Feb 23, 2023 · We recently reported that a dual inhibitor of the Xaa-Pro-cleaving M24B aminopeptidases PEPD and XPNPEP1 called CQ31 selectively activates the CARD8 inflammasome by inducing the build-up of Xaa-Pro peptides.

Aug 15, 2021 · Belts can be connected to ensure the gun never actually runs out of ammunition, and a good team can keep an M24B running for nearly forever. The M240B qualifies as a crew-served weapon, and by doctrine, the gun has three crew members.

Here we report a small molecule called CQ31 that selectively activates CARD8. CQ31 inhibits the M24B aminopeptidases prolidase (PEPD) and Xaa-Pro aminopeptidase 1 (XPNPEP1), leading to the accumulation of proline-containing peptides that inhibit DPP8/9 and thereby activate CARD8.