Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, [1] macrophages, neutrophils, helper T cells and human B-lymphoblastoid cells in response to antigenic stimulation.IL-12 belongs to the family of interleukin-12. IL-12 family is unique in comprising the only heterodimeric cytokines, which includes IL-12, IL-23, IL-27 and IL-35. [2]

Interleukin 12 (IL-12) family is comprised of 4 members, IL-12, IL-23, IL-27 and IL-35. IL-12, IL-23 and IL-27 are secreted by activated antigen presenting cells (APC) during antigen presentation to naïve T cells while IL-35 is a product of regulatory T and B cells [1–3].

Feb 1, 2003 · Interleukin-12 (IL-12) is a covalently linked heterodimer that is formed by a light chain of approximately 35 kDa (p35 or IL-12α) and a heavy chain of approximately 40 kDa (p40 or IL-12β) 9.The ...

Interleukin-12 (IL-12) was the first member of the IL-12 family of cytokines to be identified and has therefore become its eponym. It is a heterodimeric protein of two subunits (p35, p40) secreted by phagocytic cells in response to pathogens and mainly acts through STAT4 to induce IFN-γ production in T and NK cells.

The IL-12 family of cytokines influences the outcome of cancer, infection, and inflammatory diseases. Stumhofer, Hunter, and Tait review the combinatorial biology inherent to this family and the recent clinical insights that underscore the critical role of these pathways in human disease.

Interleukin-12 (IL-12) is a heterodimeric cytokine produced mostly by phagocytic cells in response to bacteria, bacterial products, and intracellular parasites, and to some degree by B lymphocytes. IL-12 induces cytokine production, primarily of IFN …

IL-12 was originally described functionally as a natural killer stimulatory factor and cytotoxic lymphocyte maturation factor70–72 produced by monocytes. IL-12 is a heterodimeric glycoprotein of approximately 70-kDa molecular weight and is composed of two unrelated glycoproteins of 40 and 35 kDa, respectively, which are linked covalently by a single disulfide bond.49 The 40-kDa …

IL-12 signals through the IL-12 receptor (IL-12R) comprised of the IL-12Rβ1 and IL-12Rβ2 subunits that are expressed on T cells, NK cells, and DCs 10, 11. IL-12 stimulates non-receptor Janus kinase 2 (JAK2) and tyrosine kinase 2 (TYK2) activities, leading to the phosphorylation of signal transducers and activators of transcription (STATs) (in ...

These IL-12 functions depend on its IL-12 and IL-12 receptor complex. IL-12 (Interleukin 12) Function IL-12 (interleukin 12) is a heterodimeric pro-inflammatory cytokine that induces the production of interferon-γ (IFN-γ), favours the differentiation of T helper 1 (TH1) cells and forms a link between innate resistance and adaptive immunity.

Oct 3, 2024 · The interleukin (IL)-12 family of cytokines, including IL-12, IL-23, IL-27, and IL-35, belongs to the hematopoietin superfamily. These unique heterodimeric cytokines consist of α and β subunits. 1 The α subunits, such as IL-12p35, IL-23p19, and IL-27p28, are homologous to IL-6 and have a four-helix bundle structure, while the β subunits, including p40 and Epstein-Barr …