NCI-H1975 [H-1975, H1975] is a cell line exhibiting epithelial morphology that was isolated in 1988 from the lungs of a nonsmoking female with non-small cell lung cancer. Use these cells …

Establishment and biological characteristics of acquired gefitinib resistance in cell line NCI-H1975/gefinitib-resistant with epidermal growth factor receptor T790M mutation.

Purified genomic DNA isolated from the NCI-H1975 human lung non-small cell carcinoma cell line (ATCC CRL-5908). This product was quantified for oncology biomarker EGFR p.T790M and …

NCI-H1975 cells are characterized by their mutation in the epidermal growth factor receptor (EGFR) gene, which makes them particularly useful for studying the mechanisms of resistance …

Potential utility of a 4th-generation EGFR-TKI and exploration of resistance mechanisms -- an in vitro study.

NCI-H1975: Human Lung Adenocarcinoma Epithelial Cell Line, Established from the primary tumor of a nonsmoking Caucasian female with non-small cell lung Adenocarcinoma

NCI-H1975 is notably characterized by specific mutations in the EGFR gene, making it a particularly useful model for studying targeted therapies for EGFR-mutant NSCLC. This cell …

The NCI-H1975 cell line is a well-established model derived from human non-small cell lung carcinoma (NSCLC), specifically adenocarcinoma. This cell line is particularly significant due …

Jun 30, 2016 · The H1975 cell line carries both an activating mutation (L858R) and a second-site mutation in EGFR (T790M) that confers resistance to small-molecule EGFR TKIs, such as …

We generated afatinib resistant clones of H1975 lung cancer cells by transient exposure of established tumors to the drug and collected the re-grown tumors. Afatinib resistant H1975 …