Sans Plexin-B1, Glial Net Tightens Around Plaques - ALZFORUM
Jun 1, 2024 · In APP/PS1 controls (left), astrocytes (green) and microglia (brown) form a wide glial net around plaques. Without Plexin-B1 to enforce cell spacing (right), glia crowd together …
Glial lipid droplets resolve ROS during sleep. - ALZFORUM
Feb 27, 2024 · The daily transfer of lipids from neurons to glia required neuronal lazarillo (NLaz), a fly apolipoprotein similar to human apolipoprotein E (APOE): knocking down NLaz reduced …
Glial Cell Communities Conspire to Drive Alzheimer’s Disease
Sep 26, 2024 · Less well understood is what role inflammation and glial changes play. Now, by analyzing single-nuclei RNA-Seq data from more than 400 postmortem brains, scientists have …
“iAssembloids” Probe Glial Roles in Neuron Survival
Jan 24, 2025 · Interestingly, they discovered that this axis is undetectable in 2D or even 3D neuron monoculture models, highlighting the need for more sophisticated models replicating …
While a Fly Sleeps, Its Glia Burn Neuronal Lipids to Refresh
Feb 27, 2024 · The daily transfer of lipids from neurons to glia required neuronal lazarillo (NLaz), a fly apolipoprotein similar to human apolipoprotein E (APOE): knocking down NLaz reduced …
Neuron-Glia Crosstalk Underlies Senescence, Impaired Lipid
Jun 7, 2024 · The authors provide evidence that lipid droplets that accumulate in aged brains are sourced by lipids from the senescent glia themselves (cell autonomous), while others suggest …
Do APOE4’s Lipid Shenanigans Trigger Tauopathy? - ALZFORUM
Nov 29, 2023 · Gene expression studies confirmed that GW3965 treatment normalized glial lipid metabolism, as well as helping neurons maintain synapse function and better degrade …
New Role for Tau: Making Lipid Droplets in Glia? | ALZFORUM
Oct 22, 2024 · When they cranked up tau expression in glia throughout the fly brain, glial lipid droplets plummeted by more than 90 percent, and peroxidated lipids accumulated. Similarly, in …
Amelioration of Tau and ApoE4-linked glial lipid ... - ALZFORUM
Nov 29, 2023 · This paper provides an important proof of concept for the role cholesterol has in mediating the effects of ApoE4 on Tau pathology. This effect might be driven through glial lipid …
Newborn Neurons in the Adult Brain: Real Deal, or Glial Imposters?
Apr 12, 2018 · Glial Impostor? DCX+ (green) cells co-expressing the oligodendrocyte marker Olig2 (red). [Courtesy of Sorrells et al., Nature, 2018.] The researchers concluded that …