Eukaryotic elongation factor 2 is a protein that in humans is encoded by the EEF2 gene. It is the archaeal and eukaryotic counterpart of bacterial EF-G. [5] [6] [7] [8] This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis.

Mar 30, 2025 · EEF2 (Eukaryotic Translation Elongation Factor 2) is a Protein Coding gene. Diseases associated with EEF2 include Spinocerebellar Ataxia 26 and Diphtheria . Among its related pathways are Peptide chain elongation and Innate Immune System .

The important component of eEFs, i.e. eEF2 promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. Mostly the eEF2 is regulated by phosphorylation and dephosphorylation by a specific kinase known as eEF2 kinase, which itself is up-regulated by various mechanisms in the eukaryotic cell.

Dec 20, 2024 · Eukaryotic elongation factor 2 (eEF2) is an essential regulator of protein synthesis that precisely elongates nascent peptides in the protein elongation process.

Eukaryotic translation elongation factor 2 (eEF2), encoded by the gene EEF2, is an essential factor involved in the elongation phase of protein translation. A specific heterozygous missense variant (p.P596H) in EEF2 was originally identified in association with autosomal dominant adult-onset spinocerebellar ataxia-26 (SCA26). More recently ...

An emerging body of research is revealing mutations in elongation factor eEF2 that are implicated in both inherited and de novo neurodevelopmental disorders. Previous structural analysis has revealed that most pathogenic amino acid substitutions map ...

Nov 23, 2021 · Here, we uncover key roles for eEF2 kinase (eEF2K) in the control of ribosome availability and p-body abundance. eEF2K acts on a sole known substrate, eEF2, to inhibit translation.

May 2, 2024 · Here, we find that FAM86A methylation of eEF2 regulates nascent elongation to promote protein synthesis and lung adenocarcinoma (LUAD) pathogenesis. The principal physiologic substrate of FAM86A is eEF2, with K525me3 modeled to facilitate productive eEF2-ribosome engagement during translocation.

May 10, 2022 · Eukaryotic elongation factor-2 (eEF2), encoded by EEF2 gene that localizes on chromosome 19 in humans and a monomeric protein of 858 amino acid residues, is a key regulator of protein synthesis. 9 eEF2 belongs to the G protein family, and undergoes conformational changes upon binding to a guanosine nucleotide. 10 …

Dec 1, 2021 · Here we report a high-resolution X-ray structure of the eukaryotic 80S ribosome in a translocation-intermediate state containing mRNA, naturally modified eEF2 and tRNAs.