The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the DRD4 gene on chromosome 11 at 11p15.5. [5] The structure of DRD4 has been reported in complex with the antipsychotic drug nemonapride. [6] As with other dopamine receptor subtypes, the D 4 receptor is activated by the neurotransmitter dopamine.

Feb 8, 2025 · D4DR Summary This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease.

We review the evidence conveying a significant and differential role of D 4.4 R and D 4.7 R in the dopaminergic and noradrenergic modulation of the frontal cortico-striatal pyramidal neuron, with implications for the moderation of constructs of impulsivity as personality traits.

DRD4 influences the postsynaptic action of dopamine and is implicated in many neurological processes, exhibits polymorphism and is one of the most studied genes in connection with psychiatric disorders.

Gene ID: 1815, updated on 8-Feb-2025. This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease.

Mar 30, 2025 · DRD4 (Dopamine Receptor D4) is a Protein Coding gene. Diseases associated with DRD4 include Attention Deficit-Hyperactivity Disorder and Autonomic Nervous System Disease. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

Jan 4, 2025 · It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking.

DRD4 encodes a putative 387-amino acid protein with 7 transmembrane domains, a potential N-linked glycosylation site, and several putative phosphorylation sites. It shares 28%, 41%, and 39% sequence homology with DRD1 (126449), DRD2 (126450) and DRD3 (126451), respectively.

Sep 14, 2016 · It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking.

Oct 23, 2024 · Dopamine receptor D4 is a member of the dopamine receptor G-protein-coupled receptor family that also includes D1, D2, D3, and D5. They are located primarily in the frontal cortex, midbrain, amygdala, and cardiovascular system. This gene encodes the D4 subtype of the dopamine receptor.