Conjunctival intraepithelial neoplasia (CIN) is noninvasive by definition; the basement membrane remains intact and the underlying substantia propria is spared. [1] [2] It is a slow-growing tumor that arises from a single mutated cell on the ocular surface. [1]

Sep 15, 2016 · CIN is an abnormal line of conjunctival (and possibly corneal) epithelial cells and represents either simple dysplasia (partial thickness of epithelial tissue) or carcinoma in situ when the lesion is full thickness. 1-4 CIN is part of the spectrum of neoplastic disorders of the conjunctiva and cornea known collectively as ocular surface ...

Some authors refer to the entire spectrum of epithelial neoplasia called “ ocular surface squamous neoplasia ”, that includes dysplasia, CIN and invasive squamous cell carcinoma. The human papilloma virus (HPV) and sunlight are considered to be the main predisposing factors for conjunctival intraepithelial neoplasia.

Mar 1, 2012 · Ocular surface squamous neoplasia (OSSN) comprises a wide spectrum of dysplastic changes to the epithelium of the cornea, limbus and conjunctiva. These changes include corneal and conjunctival intraepithelial neoplasia …

May 15, 2019 · The general clinical term of OSSN includes a spectrum of malignancies that ranges from mild epithelial dysplastic changes, such as conjunctival intraepithelial neoplasia (CIN), to more severe invasive carcinoma that invades through the basement membrane into the substantia propria, such as squamous cell carcinoma.

Apr 20, 2022 · Conjunctival intraepithelial neoplasia is characterized by a proliferation of neoplastic squamous cells showing cellular atypia. It is considered a premalignant lesion that may progress to invasive squamous cell carcinoma.

Squamous conjunctival neoplasia (SCN) is most commonly found in older white males (76%). The average age of patients affected by SCN is 56. This tumor, said to make up 14% of all primary ocular and orbital tumors is related to sun exposure. Sunlight, particularly ultraviolet-B (UV-B) radiation can cause DNA damage, mutations, and cancerous cells.

Jul 31, 2023 · Ocular surface squamous neoplasia is a broad entity that comprises the spectrum of squamous neoplasms of conjunctiva and cornea. The varied malignancies include conjunctival intraepithelial neoplasia (CIN), corneal epithelial dysplasia, squamous cell carcinoma (SCC), and mucoepidermoid carcinoma.

Conjunctival intraepithelial neoplasia (CIN) with full thickness dysplasia (squamous cell carcinoma in situ) Category (ies): Cornea, External Disease Contributor: John Chen, MD, PhD Photographer: Cindy Montague, CRA

Jan 1, 2011 · Conjunctival intraepithelial neoplasia (CIN) is the most common tumor of the ocular surface and is a precursor to invasive squamous cell carcinoma. CIN comprises a spectrum of premalignant epithelial neoplasia that usually begins near the limbus and spreads to the cornea.