Chemokine (C-C motif) ligand 21 (CCL21) is a small cytokine belonging to the CC chemokine family. This chemokine is also known as 6Ckine (because it has six conserved cysteine residues instead of the four cysteines typical to chemokines), exodus-2, and secondary lymphoid-tissue chemokine (SLC).

Mar 30, 2025 · CCL21 (C-C Motif Chemokine Ligand 21) is a Protein Coding gene. Diseases associated with CCL21 include Periapical Periodontitis and Central Nervous System Lymphoma. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway.

CCL21 is critical in mediating activated DCs and T cells to lymph system niches and triggering subsequent immune response to foreign antigen, therefore providing the rationale for CCL21 based cancer immunotherapy.

CCL21 promotes immune activity in the tumor microenvironment (TME) by colocalizing dendritic cells (DC) and T cells programing ectopic lymph node architectural structures that correlate with cancer prognosis. Innovative strategies to deliver CCL21 in cancer patients will reactivate the downregulated …

In this review we discuss our experience with efforts to restore host APC and T cell activities in the lung cancer microenvironment by intratumoral administration of dendritic cells (DC) expressing the CCR7 receptor ligand CCL21 (secondary lymphoid chemokine, SLC).

CCL21 is a homeostatic chemokine constitutively produced in secondary lymphoid organs (SLOs) where it is involved in CCR7 + naïve and central memory T-cell homing via high endothelial venules (HEVs).

CCL21/CCR7 prevents apoptosis by upregulating the expression of bcl-2 and by downregulating the expression of bax and caspase-3 potentially via the ERK pathway in non-small cell lung cancer cell lines; CCL21 was more localized to chondrocytes and meniscal cells during the development of osteoarthritis in mice.

CCL21 is a risk factor for Rheumatoid arthritis (RA). CCL21 is highly elevated in RA synovial fluid and attracts circulating monocytes into the inflamed joint. CCL21 differentiates monocytes into a unique subtype of macrophages.

Jan 1, 2016 · CCL21 mediates the recruitment and co-localization of naive lymphocytes and antigen-stimulated DC into T-cell zones of secondary lymphoid organs, facilitating T-cell activation. In this chapter, we discuss CCL21 as a novel agent to …

The chemokine CCL21 regulates immune and cancer cell migration through its receptor CCR7. The Ccl21a gene encodes the isoform CCL21-Ser, predominantly expressed in the thymic medulla and the secondary lymphoid tissues. This study examined the roles of CCL21-Ser in the antitumor immune response in Ccl21a-knockout (KO) mice.