Jun 9, 2022 · Also known as c-kit, stem cell factor receptor, mast cell growth factor (Appl Immunohistochem Mol Morphol 2005;13:205) Pathophysiology Has activating or gain of function mutations in most GISTs, often at exon 11, less often at exons 9 and 13 ( Hum Pathol 2002;33:484 , Cancer Med 2020;9:6485 , Cureus 2022;14:e20868 )

Aug 7, 2023 · The most common c-KIT mutation is KIT D816V, while cutaneous mastocytosis has more frequent non-D816V codon 816 mutations Mast cell release of mediators including histamine may contribute to increased osteoblast activity, activation of osteoclasts and formation of sclerotic lesions

Nov 25, 2019 · c-KIT / CD117 95% (Am J Surg Pathol 2009;33:1401) Membranous, diffusely cytoplasmic or concentrated in a dot-like perinuclear pattern. CD34 82% (Am J Surg Pathol 2005;29:52) versus 40% in small intestinal GIST (Am J Surg Pathol 2006;30:477) SMA 18% (Am J Surg Pathol 2005;29:52) versus 34% in small intestinal GIST (Am J Surg Pathol 2006;30:477)

Small intestine: chromogranin c-kit / CD117 DOG1 Ki67 synaptophysin Stomach: chromogranin c-kit / CD117 claudin 18.2 (pending) DOG1 desmin EBER1 / 2 / LMP gastrin (pending) Helicobacter pylori HER2 stomach GEJ INSM1 Ki67 S100 SMA synaptophysin Warthin-Starry GU / adrenal Adrenal: calretinin chromogranin CK7 GATA3 GD2 (pending) inhibin MelanA ...

5 days ago · KIT is the gene encoding a transmembrane tyrosine kinase receptor, involved in both the MAP kinase and AKT pathways, which are intimately involved with cell proliferation and survival (J Clin Oncol 2013;31:3176, Int J Biol Sci 2013;9:435)

Sep 21, 2020 · Well circumscribed lesion; usually no pseudocapsule, tumor directly abuts the renal parenchyma (Am J Surg Pathol 1997;21:1, J Kidney Cancer VHL 2017;4:1)

D. Classically, chromophobe renal cell carcinoma would be positive for CK7, c-Kit (or CD117) and Hale’s colloidal iron. Oncocytoma may demonstrate scattered CK7 positivity while conventional clear cell RCC is usually CK7 negative.

Feb 16, 2022 · However, due to the lack of sensitivity and specificity and emerging utility for PAX8, CAIX, CK7 and CD117 (c-kit), RCC has become less commonly used by pathologists (Histopathology 2020;77:659 Hum Pathol 2021 May 4 [Epub ahead of print])

Jan 11, 2021 · Comment: Epithelial tumor showing solid growth pattern composed of comprised of eosinophilic cells with fine granular eosinophilic cytoplasm, perinuclear halo and round, oval to raisinoid nuclei. No pale cell was observed. Immunohistochemistry positive for CK7 and c-kit and negative for vimentin.

May 24, 2022 · Unfavorable prognostic features: Clinical: ↑ age, ↑ LDH, Eastern Cooperative Oncology Group (ECOG) ≥ 2, Ann Arbor stage III / IV, extranodal disease, bulky disease (J Clin Oncol 2010;28:2373, Blood 2014;123:837)