RANKL - Wikipedia
RANKL has been identified to affect the immune system and control bone regeneration and remodeling. RANKL is an apoptosis regulator gene, a binding partner of osteoprotegerin …
RANKL biology: bone metabolism, the immune system, and beyond
RANKL was first discovered as a T cell-derived activator of dendritic cells (DCs) and has many functions in the immune system, including organogenesis, cellular development. The …
RANKL - an overview | ScienceDirect Topics
RANKL is a transmembrane molecule expressed by mesenchymal cell and lymphocytes. The soluble form of RANKL is a consequence of proteolytic cleavage. RANKL binds to RANK on …
RANKL-RANK signaling regulates osteoblast differentiation and …
Nov 27, 2018 · RANKL signaling drives osteoclastogenesis. In BMSCs, RANKL binding to RANK activates RANKL forward signaling, which inhibits osteoblast differentiation.
RANKL biology: bone metabolism, the immune system, and beyond
Feb 7, 2020 · RANKL was first discovered as a T cell-derived activator of dendritic cells (DCs) and has many functions in the immune system, including organogenesis, cellular development. …
Bone Signaling & RANKL - Basic Science - Orthobullets
Jul 27, 2024 · RANKL (ligand) is secreted by osteoblasts and binds to the RANK receptor on osteoclast precursor and mature osteoclast cells
RANK, RANKL and osteoprotegerin in bone biology and disease
RANKL is a tumour necrosis factor (TNF)-related cytokine expressed by various bone cells including osteoblasts and their immature precursors , T lymphocytes , B lymphocytes and …
RANKL biology: bone metabolism, the immune system, and beyond
Feb 7, 2020 · RANKL was first discovered as a T cell-derived activator of dendritic cells (DCs) and has many functions in the immune system, including organogenesis, cellular development. …
Roles of the RANKL–RANK axis in antitumour immunity - Nature
Sep 19, 2018 · We highlight the role of immune cells as sources of RANK and RANKL in the tumour microenvironment and review data on RANKL inhibition in mouse models of cancer.
RANKL Biology - PMC
RANKL regulates osteolytic bone metastasis through the stimulation of cancer cell migration toward the bone. RANKL acts directly on RANK-expressing tumor cells and promotes cell …