Ku70 - Wikipedia
Ku70 is a heterodimeric protein made up of Ku70 and Ku80, which together form Ku. In humans, is encoded by the XRCC6 gene. [5] [6] Ku70 plays a critical role in the DNA repair, …
The Multifaceted Roles of Ku70/80 - PMC - PubMed Central (PMC)
The heterodimer Ku70/80 (Ku) is a central actor of the c-NHEJ as it rapidly recognizes broken DNA ends in the cell and protects them from nuclease activity. It subsequently recruits many c …
Ku70 senses cytosolic DNA and assembles a tumor-suppressive
Jan 26, 2024 · Mechanistically, Ku70 translocates from the nucleus into the cytoplasm where it binds to cytosolic DNA and interacts with the GTPase Ras and the kinase Raf, forming a …
Cancer-Cooling Protein Can Stop Disease Spreading - Newsweek
Jan 26, 2024 · An immune system protein named Ku70 may be triggered to combat bowel cancer after being "switched on" by a cocktail of drugs, according to a new paper in the journal …
SETD4-mediated KU70 methylation suppresses apoptosis - Cell …
May 10, 2022 · The KU70-K570R (mouse Ku70-K568R) mutation dampens the anti-apoptosis activity of KU70. Our study identifies KU70 as a non-histone substrate of SETD4, discovers a …
The Role of Ku70 as a Cytosolic DNA Sensor in Innate Immunity …
Oct 21, 2021 · We explored the unique structure of Ku70 binding with DNA; illustrated, with evidence, how Ku70, as a nuclear protein, responds to extracellular DNA stimulation; and …
Molecular cloning, subcellular localization, and rapid ... - Nature
Jan 12, 2024 · Ku70 is a multifunctional protein with pivotal roles in DNA repair via non-homologous end-joining, V(D)J recombination, telomere maintenance, and neuronal apoptosis …
Novel Colon Cancer Biomarker That May Deactivate Cancer Cells …
Jan 26, 2024 · Researchers from the Australian National University (ANU) have uncovered that a protein in the immune system can be manipulated to help overcome colon cancer. The protein, …
Ku70 Is a Novel Cytosolic DNA Sensor that Induces Type-III Rather …
The knockdown studies and the reporter assay revealed that Ku70 is a novel DNA sensor inducing the IFN-lambda1 activation. The functional analysis of IFNL1 promoter revealed that …
A new phosphorylated form of Ku70 identified in resistant …
Sep 9, 2015 · In vitro in different cancer cell lines, Ku70 phosphorylation occurs in a heterodimer Ku70/Ku80 complex within minutes of genotoxic stress, necessitating its interaction with DNA …