p53, also known as tumor protein p53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is …

TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of …

p53′s tumor-suppressive activity has been found to limit tumor cell proliferation not only within cells but also in the extracellular space. Thus, the loss of p53 has a profound impact on the …

Genetic mutations that affect ribosomal function, DNA repair, and the control of mitosis through the centriole all activate p53, and this activation is critical for the observed developmental …

p53 is an important tumour-suppressor protein that is altered in most cancers. p53 activates various responses, including cell-cycle arrest and apoptosis. Each of these appears to …

Feb 28, 2003 · This tutorial describes the structure and function of the p53 protein, how its activity is regulated in cells, and how mutant versions of p53 can lead to cancer. The Click & Learn …

Mar 28, 2024 · We describe here the paradox of how, depending on its mutational status in cancer, p53 can be both a tumor suppressor and an apparent oncogene. The major challenge …

May 9, 2024 · p53 plays a central role in suppressing tumorigenesis. In this issue, Liu et al. review the complexity of different layers of p53 regulation, and the recent advance of the p53 pathway …

Aug 24, 2023 · p53 ensures that cells repair any damaged DNA before cell division by inducing cell cycle arrest to allow time for DNA repair or to force the cell to undergo apoptosis via …

TP53 is the most commonly mutated gene in human cancer with over 100,000 literature citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a history …