Jan 1, 2008 · Homologous recombination (HR) is a DNA metabolic process found in all forms of life that provides high-fidelity, template-dependent repair or tolerance of complex DNA …

Homologous recombination (HR) is a DNA metabolic process found in all forms of life that provides high-fidelity, template-dependent repair or tolerance of complex DNA damages …

Homologous recombination is one major pathway to repair such breaks. In this review, we discuss the repair of DNA double-strand breaks (DSBs) using a homologous DNA sequence (i.e., …

Jul 6, 2018 · Here, we discuss the DNA transactions and enzymatic activities required for this elegantly orchestrated process in the context of the repair of DNA double-strand breaks in …

Homologous recombination enables the cell to access and copy intact DNA sequence information in trans, particularly to repair DNA damage affecting both strands of the double helix. Here, we …

Jan 1, 2017 · Homologous recombination repair is a DNA repair process that includes the invasion of an undamaged DNA molecule by a damaged molecule of identical or very similar …

Nov 7, 2002 · Double-strand breaks occur during DNA replication and are also induced by ionizing radiation. There are at least two pathways which can repair such breaks: non-homologous end …

5 days ago · Deficiencies in high-fidelity DNA repair by homologous recombination lead to dependence on DNA polymerase θ, which identifies DNA microhomologies in 3′ single …

Homologous recombination (HR) comprises a series of interrelated pathways that function in the repair of DNA double-stranded breaks (DSBs) and interstrand crosslinks (ICLs). In addition, …

BRCA1/2 proteins play critical roles in DNA repair by the HRR pathway and act as tumor suppressors. Cells with a compromised HRR pathway caused by alterations in BRCA1/2 or …