A viral vector vaccine is a vaccine that uses a viral vector to deliver genetic material that can be transcribed by the recipient's host cells as mRNA coding for a desired protein, or antigen, to elicit an immune response. [1]

Dec 29, 2020 · Viral vector-based vaccines use a harmless virus to smuggle the instructions for making antigens from the disease-causing virus into cells, triggering protective immunity against it.

Dec 22, 2022 · Viral vector vaccines use a modified version of a different virus as a vector to deliver protection. Several different viruses have been used as vectors, including influenza, vesicular stomatitis virus (VSV), measles virus, and adenovirus, which causes the common cold.

Viral vector vaccines use a harmless virus to deliver to the hosts cells the genetic code of the antigen you want the immune system to fight. “They are basically a gene delivery system,” says Dr. Scully.

Jan 30, 2025 · In this type of vaccine, material from the virus that causes COVID-19 is placed in a modified version of a different virus. This different virus is called a viral vector. The viral vector gives cells instructions to make copies of the COVID-19 virus S protein.

Apr 7, 2023 · Viral vector vaccines consist of viral particles whose genomes have been modified to contain one or more foreign genes encoding the targeted antigens. The rationale for...

Viral vector vaccines utilise the capacity of viruses to infect cells and induce broad immune responses. Heterologous antigens are expressed by the virus, usually from genes engineered into the viral genome, and induce antigen-specific humoral and cellular immune responses.

Viral vector-based vaccines can enhance immunogenicity without an adjuvant and induce a robust cytotoxic T lymphocyte (CTL) response to eliminate virus-infected cells. During the last several decades, many types of viruses have been developed as vaccine vectors.

For viral vector vaccines, viral vectors are genetically engineered to introduce target genes encoding key antigens of pathogens. Currently, widely used viral vectors include adenovirus, measles virus, influenza viruses and poxvirus [2].

Viral vectors are a relatively new vaccine platform that relies on recombinant viruses to deliver selected immunogens into the host. In response to the SARS-CoV-2 pandemic, the development and subsequent rollout of adenoviral vector vaccines has shown the utility, impact, scalability and efficacy of this platform.